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Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function

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dc.contributor.author김성렬-
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author박혜정-
dc.contributor.author이재현-
dc.date.accessioned2020-12-01T16:55:12Z-
dc.date.available2020-12-01T16:55:12Z-
dc.date.issued2020-09-
dc.identifier.issn2092-7355-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180045-
dc.description.abstractPurpose: It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. We investigated the applicability of IOS for asthma patients with preserved lung function. Methods: Between 2015 and 2018, 1,248 adult asthmatic patients suspected of having asthma who visited the Allergy and Asthma Center of Severance Hospital underwent both spirometry and IOS. Consequently, 784 patients had asthma, 111 had chronic obstructive lung disease (COPD) or asthma-COPD overlap, and 7 had parenchymal lung disease. The remaining 346 patients had chronic cough without underlying lung or airway disease. Among the 784 asthmatic patients, 191 with decreased lung function (predicted forced expiratory volume in 1 second [FEV1] < 80%) were excluded. Propensity score matching was performed to adjust baseline characteristics between 346 non-asthmatic and 593 asthmatic patients with preserved lung function. Subsequently, we compared the spirometry and IOS parameters between the 329 asthmatic and 329 non-asthmatic patients. Results: Multiple logistic regression analysis showed that the area of reactance (AX) was associated with asthma with preserved lung function. In receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) of AX (AUC = 0.6823) for asthma was not significantly different from that of FEV1 (AUC = 0.6758). However, the AUC of a combination of AX and FEV1 (AUC = 0.7437) for asthma was significantly higher than that of FEV1 alone. The cutoff value of AX was 0.51 kPa/L in univariate ROC analysis. Conclusions: AX is associated with adult asthma with preserved lung function. Performing spirometry together with IOS is more beneficial than performing spirometry alone for diagnosing asthma in adult patients with preserved lung function.-
dc.description.statementOfResponsibilityopen-
dc.publisherKorean Academy of Pediatric Allergy and Respiratory Disease-
dc.relation.isPartOfALLERGY ASTHMA & IMMUNOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleApplication of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSung Ryeol Kim-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorNak Hoon Son-
dc.contributor.googleauthorJinyeong Moon-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorKyungchul Kim-
dc.contributor.googleauthorJung Won Park-
dc.contributor.googleauthorJae Hyun Lee-
dc.identifier.doi10.4168/aair.2020.12.5.832-
dc.contributor.localIdA00566-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA01769-
dc.contributor.localIdA03086-
dc.relation.journalcodeJ00064-
dc.identifier.eissn2092-7363-
dc.identifier.pmid32638563-
dc.subject.keywordAsthma-
dc.subject.keywordairway-
dc.subject.keywordlung function-
dc.subject.keywordoscillometry-
dc.subject.keywordspirometry-
dc.contributor.alternativeNameKim, Sung Ryeol-
dc.contributor.affiliatedAuthor김성렬-
dc.contributor.affiliatedAuthor박경희-
dc.contributor.affiliatedAuthor박중원-
dc.contributor.affiliatedAuthor박혜정-
dc.contributor.affiliatedAuthor이재현-
dc.citation.volume12-
dc.citation.number5-
dc.citation.startPage832-
dc.citation.endPage843-
dc.identifier.bibliographicCitationALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.12(5) : 832-843, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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