Cited 18 times in
Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation
DC Field | Value | Language |
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dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2020-12-01T16:51:18Z | - |
dc.date.available | 2020-12-01T16:51:18Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180008 | - |
dc.description.abstract | The underlying mechanism of necroptosis in relation to cancer is still unclear. Here, MYC, a potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the RIPK1-RIPK3 complex. Gene set enrichment analyses reveal that the MYC pathway is the most prominently down-regulated signaling pathway during necroptosis. Depletion or deletion of MYC promotes the RIPK1-RIPK3 interaction, thereby stabilizing the RIPK1 and RIPK3 proteins and facilitating necroptosis. Interestingly, MYC binds to RIPK3 in the cytoplasm and inhibits the interaction between RIPK1 and RIPK3 in vitro. Furthermore, MYC-nick, a truncated form that is mainly localized in the cytoplasm, prevented TNF-induced necroptosis. Finally, down-regulation of MYC enhances necroptosis in leukemia cells and suppresses tumor growth in a xenograft model upon treatment with birinapant and emricasan. MYC-mediated suppression of necroptosis is a mechanism of necroptosis resistance in cancer, and approaches targeting MYC to induce necroptosis represent an attractive therapeutic strategy for cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukemia / genetics | - |
dc.subject.MESH | Leukemia / metabolism* | - |
dc.subject.MESH | Leukemia / physiopathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Necroptosis | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc / genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc / metabolism* | - |
dc.subject.MESH | Receptor-Interacting Protein Serine-Threonine Kinases / genetics | - |
dc.subject.MESH | Receptor-Interacting Protein Serine-Threonine Kinases / metabolism* | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Daehyeon Seong | - |
dc.contributor.googleauthor | Manhyung Jeong | - |
dc.contributor.googleauthor | Jinho Seo | - |
dc.contributor.googleauthor | Ji-Yoon Lee | - |
dc.contributor.googleauthor | Chi Hyun Hwang | - |
dc.contributor.googleauthor | Ho-Chul Shin | - |
dc.contributor.googleauthor | Jeong Yoon Shin | - |
dc.contributor.googleauthor | Young Woo Nam | - |
dc.contributor.googleauthor | Jeong Yeon Jo | - |
dc.contributor.googleauthor | Haeseung Lee | - |
dc.contributor.googleauthor | Hye-Jung Kim | - |
dc.contributor.googleauthor | Hwa-Ryeon Kim | - |
dc.contributor.googleauthor | Ji Hoon Oh | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Seung Jun Kim | - |
dc.contributor.googleauthor | Jae-Seok Roe | - |
dc.contributor.googleauthor | Wankyu Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Kwang-Hee Bae | - |
dc.contributor.googleauthor | Sang Chul Lee | - |
dc.contributor.googleauthor | Andrew Oberst | - |
dc.contributor.googleauthor | Peter Vandenabeele | - |
dc.contributor.googleauthor | Dong Hoon Shin | - |
dc.contributor.googleauthor | Eun-Woo Lee | - |
dc.contributor.googleauthor | Jaewhan Song | - |
dc.identifier.doi | 10.1073/pnas.2000979117 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 32753382 | - |
dc.subject.keyword | MYC | - |
dc.subject.keyword | RIPK3 | - |
dc.subject.keyword | TNF-α | - |
dc.subject.keyword | necroptosis | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | 정준원 | - |
dc.citation.volume | 117 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 19982 | - |
dc.citation.endPage | 19993 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.117(33) : 19982-19993, 2020-08 | - |
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