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Expression of EMP1, EMP2, and EMP3 in breast phyllodes tumors

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dc.contributor.author구자승-
dc.contributor.author차윤진-
dc.date.accessioned2020-12-01T16:50:42Z-
dc.date.available2020-12-01T16:50:42Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180001-
dc.description.abstractPurpose: Phyllodes tumors (PTs) are biphasic tumors accounting for 0.3-1.5% of all breast tumors. Epithelial membrane proteins (EMPs) have been reported in various malignant tumors but their expression in PTs is unclear. In this study, we aimed to evaluate the expression of EMP1, EMP2, and EMP3 in breast phyllodes tumors (PTs), and to investigate their clinical implications. Methods: In total, 185 PTs were used for constructing a tissue microarray. Immunohistochemical staining for EMP1, EMP2, and EMP3 was performed, and the results were analyzed along with the clinicopathologic parameters. Results: In total, 185 PTs were included in this study, and comprised 138 benign, 32 borderline, and 15 malignant PTs. In malignant PTs, the epithelial component showed decreased expression of EMP1 (P = 0.027), EMP2 (P = 0.004), and EMP3 (P = 0.032), compared to the benign and borderline PTs. Conversely, stromal component of borderline and malignant PTs showed higher expression of EMP1 (P = 0.027), EMP2 (P = 0.004), and EMP3 (P = 0.032) compared to benign PTs. Expression of EMP1 and EMP3 correlated positively with stromal cellularity and cellular atypia (P < 0.001). In the univariate analysis, stromal EMP3 was associated with shorter disease-free survival (P < 0.001), and shorter overall survival (P = 0.034). Conclusion: The expression of EMP1, EMP2, and EMP3 is decreased in the epithelial component and is increased in the stromal component of PT with higher histologic grade. Thus, stromal EMP3 expression may serve as an independent prognostic factor in PT.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers, Tumor / metabolism-
dc.subject.MESHBreast Neoplasms / metabolism*-
dc.subject.MESHBreast Neoplasms / pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMembrane Glycoproteins / metabolism*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Proteins / metabolism*-
dc.subject.MESHPhyllodes Tumor / metabolism*-
dc.subject.MESHPhyllodes Tumor / pathology-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptors, Cell Surface / metabolism*-
dc.subject.MESHStromal Cells / metabolism-
dc.subject.MESHStromal Cells / pathology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTissue Array Analysis-
dc.titleExpression of EMP1, EMP2, and EMP3 in breast phyllodes tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1371/journal.pone.0238466-
dc.contributor.localIdA00198-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid32857809-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.contributor.affiliatedAuthor차윤진-
dc.citation.volume15-
dc.citation.number8-
dc.citation.startPagee0238466-
dc.identifier.bibliographicCitationPLOS ONE, Vol.15(8) : e0238466, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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