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Development of a Korean Culture-Friendly Olfactory Function Test and Optimization of a Diagnostic Cutoff Value

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dc.contributor.author김진원-
dc.contributor.author김창훈-
dc.contributor.author남재성-
dc.contributor.author윤주헌-
dc.contributor.author조형주-
dc.contributor.author하종균-
dc.contributor.author박정진-
dc.date.accessioned2020-12-01T16:48:32Z-
dc.date.available2020-12-01T16:48:32Z-
dc.date.issued2020-08-
dc.identifier.issn1976-8710-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179988-
dc.description.abstractObjectives: Cultural familiarity and safety must be considered when assessing olfactory ability. The YSK olfactory function (YOF) test is a new olfactory function test using culturally familiar odorants to Koreans. Methods: The YOF test comprises three subtests for threshold (T), discrimination (D), and identification (I). The identification test included eight universal and four Korean culture-friendly odorants, which were selected considering eight major functional groups. Data were obtained from 1,127 subjects over 19 years old. Subjects were classified as having normosmia (n=542), hyposmia (n=472), and anosmia (n=113) by self-reported olfactory function. The YOF test and the Korean version of the Sniffin' stick test (KVSS-II) were performed on the same day in random order. Diagnostic cutoffs for anosmia and hyposmia were calculated using the Youden index (J). Results: The mean values for each T/D/I subtest and the total TDI score were as follows: normosmia (T, 4.6±2.3; D, 8.6±2.1; I, 11.1±1.7; TDI score, 24.2±4.5); hyposmia (T, 3.3±2.2; D, 7.1±2.5; I, 9.2±3.1; TDI score, 19.5±6.4); and anosmia (T, 1.7±1.2; D, 5.1±2.5; I, 5.0±3.2; TDI score, 11.8±5.6). The correlation coefficients between the YOF test and KVSS-II were 0.57, 0.65, 0.80, and 0.86 for T, D, I, and the TDI score, respectively (P<0.001). The diagnostic cutoffs were a TDI score ≤14.5 (J=0.67) for anosmia and 14.5(TDI score ≤21.0 (J=0.38) for hyposmia. The diagnostic efficacy of the YOF test (area under the curve [AUC], 0.88) was equivalent to that of the KVSS-II (AUC, 0.88; P=0.843; DeLong method). Conclusion: The YOF test is a new olfactory test using safe and Korean culture-friendly odorants. It showed equivalent validity with the conventional olfactory function test. Furthermore, the YOF test provides information on the major functional groups of odorants, potentially enabling a more comprehensive interpretation for patients with olfactory disorders.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Otorhinolaryngology--Head and Neck Surgery-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDevelopment of a Korean Culture-Friendly Olfactory Function Test and Optimization of a Diagnostic Cutoff Value-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorJong-Gyun Ha-
dc.contributor.googleauthorJinwon Kim-
dc.contributor.googleauthorJae Sung Nam-
dc.contributor.googleauthorJeong Jin Park-
dc.contributor.googleauthorHyung-Ju Cho-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorChang-Hoon Kim-
dc.identifier.doi10.21053/ceo.2020.00864-
dc.contributor.localIdA04734-
dc.contributor.localIdA01050-
dc.contributor.localIdA05623-
dc.contributor.localIdA02604-
dc.contributor.localIdA03936-
dc.contributor.localIdA04810-
dc.relation.journalcodeJ00552-
dc.identifier.eissn2005-0720-
dc.identifier.pmid32668827-
dc.subject.keywordCulture-
dc.subject.keywordOdorants-
dc.subject.keywordOlfactory Perception-
dc.subject.keywordSmell-
dc.contributor.alternativeNameKim, Jin Won-
dc.contributor.affiliatedAuthor김진원-
dc.contributor.affiliatedAuthor김창훈-
dc.contributor.affiliatedAuthor남재성-
dc.contributor.affiliatedAuthor윤주헌-
dc.contributor.affiliatedAuthor조형주-
dc.contributor.affiliatedAuthor하종균-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage274-
dc.citation.endPage284-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, Vol.13(3) : 274-284, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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