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Male sex and Breslow thickness are important risk factors for recurrence of localized melanoma in Korean populations

Authors
 Yeongjoo Oh  ;  Sooyie Choi  ;  Mi Yeon Cho  ;  Kyoung Ae Nam  ;  Sang Joon Shin  ;  Jee Suk Chang  ;  Byung Ho Oh  ;  Mi Ryung Roh  ;  Kee Yang Chung 
Citation
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.83(4) : 1071-1079, 2020-09 
Journal Title
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 
ISSN
 0190-9622 
Issue Date
2020-09
Keywords
Asian melanoma ; localized melanoma ; melanoma ; recurrence ; sex disparity
Abstract
Background: Predicting the recurrence of localized melanoma is important; however, studies investigating risk factors for recurrence of localized melanoma are lacking in Asian populations. Objective: To identify risk factors for recurrence of localized melanoma in Korean patients. Methods: We retrospectively reviewed patients with cutaneous melanoma without evidence of metastasis from 2000 to 2017. Logistic and Cox regression analyses were conducted for recurrence. The average follow-up time was 46.2 months. Results: We reviewed the data of 340 patients diagnosed with cutaneous melanoma and staged as melanoma in situ, stages I and II. Acral melanoma (70.3%, 239/340) was the predominant subtype. Ninety-two patients (27.1%) had a recurrence after primary melanoma removal (29 local recurrences, 49 regional metastases, and 28 distant metastases). Some patients had multiple types of recurrence at the same time. Male sex (P = .030) and Breslow thickness greater than 1 mm (P = .008) correlated with an increased risk of recurrence. Breslow thickness greater than 2.5 mm in males and greater than 4 mm in females showed a higher predictive value for recurrence than traditional stages IIB and IIC (hazard ratio 3.743 vs 2.972). Limitations: This was a single-center retrospective study. Conclusion: In patients with localized cutaneous melanoma, male sex and Breslow thickness are the most important prognostic factors for recurrence in Korean populations. Different cutoff values of Breslow thickness may better predict recurrence according to sex.
Full Text
https://www.sciencedirect.com/science/article/pii/S0190962219327732
DOI
10.1016/j.jaad.2019.09.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Oh, Byung Ho(오병호) ORCID logo https://orcid.org/0000-0001-9575-5665
Oh, Yeongjoo(오영주) ORCID logo https://orcid.org/0000-0003-4973-9335
Chang, Jee Suk(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
Cho, Mi Yeon(조미연) ORCID logo https://orcid.org/0000-0001-9676-6681
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179977
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