Cited 5 times in
L-glutamine as a T 2 exchange contrast agent
DC Field | Value | Language |
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dc.contributor.author | 손혜영 | - |
dc.contributor.author | 주찬규 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2020-12-01T16:42:18Z | - |
dc.date.available | 2020-12-01T16:42:18Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179934 | - |
dc.description.abstract | Purpose: The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated. Methods: The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2 -weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion. Results: The T2 relaxivity caused by the exchange (R2ex ) at 37°C was 0.069 s-1 mM-1 and 0.102 s-1 mM-1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1-6.7 was in the 0.097-0.1 s-1 mM-1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2 -weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor CONCLUSION: L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | MAGNETIC RESONANCE IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | L-glutamine as a T 2 exchange contrast agent | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Chan Gyu Joo | - |
dc.contributor.googleauthor | Seung-Hyun Yang | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Hye-Young Son | - |
dc.contributor.googleauthor | Dong-Hyun Kim | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.identifier.doi | 10.1002/mrm.28305 | - |
dc.contributor.localId | A04589 | - |
dc.contributor.localId | A05044 | - |
dc.relation.journalcode | J02179 | - |
dc.identifier.eissn | 1522-2594 | - |
dc.identifier.pmid | 32406063 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.28305 | - |
dc.subject.keyword | cancer imaging | - |
dc.subject.keyword | exchange contrast agent | - |
dc.subject.keyword | glutamine | - |
dc.contributor.alternativeName | Son, Hye Yeong | - |
dc.contributor.affiliatedAuthor | 손혜영 | - |
dc.contributor.affiliatedAuthor | 주찬규 | - |
dc.citation.volume | 84 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2055 | - |
dc.citation.endPage | 2062 | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IN MEDICINE, Vol.84(4) : 2055-2062, 2020-10 | - |
dc.identifier.rimsid | 67360 | - |
dc.type.rims | ART | - |
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