0 59

Cited 0 times in

L-glutamine as a T 2 exchange contrast agent

DC FieldValueLanguage
dc.contributor.author손혜영-
dc.contributor.author주찬규-
dc.contributor.author허용민-
dc.contributor.author허용민-
dc.date.accessioned2020-12-01T16:42:18Z-
dc.date.available2020-12-01T16:42:18Z-
dc.date.issued2020-10-
dc.identifier.issn0740-3194-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179934-
dc.description.abstractPurpose: The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated. Methods: The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2 -weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion. Results: The T2 relaxivity caused by the exchange (R2ex ) at 37°C was 0.069 s-1 mM-1 and 0.102 s-1 mM-1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1-6.7 was in the 0.097-0.1 s-1 mM-1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2 -weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor CONCLUSION: L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfMAGNETIC RESONANCE IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleL-glutamine as a T 2 exchange contrast agent-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorChan Gyu Joo-
dc.contributor.googleauthorSeung-Hyun Yang-
dc.contributor.googleauthorYuna Choi-
dc.contributor.googleauthorHye-Young Son-
dc.contributor.googleauthorDong-Hyun Kim-
dc.contributor.googleauthorYong-Min Huh-
dc.identifier.doi10.1002/mrm.28305-
dc.contributor.localIdA04589-
dc.contributor.localIdA05044-
dc.contributor.localIdA05044-
dc.relation.journalcodeJ02179-
dc.identifier.eissn1522-2594-
dc.identifier.pmid32406063-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/mrm.28305-
dc.subject.keywordcancer imaging-
dc.subject.keywordexchange contrast agent-
dc.subject.keywordglutamine-
dc.contributor.alternativeNameSon, Hye Yeong-
dc.contributor.affiliatedAuthor손혜영-
dc.contributor.affiliatedAuthor주찬규-
dc.contributor.affiliatedAuthor주찬규-
dc.citation.volume84-
dc.citation.number4-
dc.citation.startPage2055-
dc.citation.endPage2062-
dc.identifier.bibliographicCitationMAGNETIC RESONANCE IN MEDICINE, Vol.84(4) : 2055-2062, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.