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L-glutamine as a T 2 exchange contrast agent

Authors
 Chan Gyu Joo  ;  Seung-Hyun Yang  ;  Yuna Choi  ;  Hye-Young Son  ;  Dong-Hyun Kim  ;  Yong-Min Huh 
Citation
 MAGNETIC RESONANCE IN MEDICINE, Vol.84(4) : 2055-2062, 2020-10 
Journal Title
 MAGNETIC RESONANCE IN MEDICINE 
ISSN
 0740-3194 
Issue Date
2020-10
Keywords
cancer imaging ; exchange contrast agent ; glutamine
Abstract
Purpose: The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated. Methods: The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2 -weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion. Results: The T2 relaxivity caused by the exchange (R2ex ) at 37°C was 0.069 s-1 mM-1 and 0.102 s-1 mM-1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1-6.7 was in the 0.097-0.1 s-1 mM-1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2 -weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor CONCLUSION: L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.28305
DOI
10.1002/mrm.28305
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Joo, Chan Gyu(주찬규) ORCID logo https://orcid.org/0000-0002-1415-9245
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179934
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