0 42

Cited 0 times in

18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy

Authors
 Hee Jin Kim  ;  Hanna Cho  ;  David J Werring  ;  Young Kyoung Jang  ;  Yeo Jin Kim  ;  Jin San Lee  ;  Juyoun Lee  ;  Soomin Jun  ;  Seongbeom Park  ;  Young Hoon Ryu  ;  Jae Yong Choi  ;  Young Seok Cho  ;  Seung Hwan Moon  ;  Duk L Na  ;  Chul Hyoung Lyoo  ;  Sang Won Seo 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.57(3) : 711-716, 2017 
Journal Title
 JOURNAL OF ALZHEIMERS DISEASE 
ISSN
 1387-2877 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Aniline Compounds / metabolism ; Brain / diagnostic imaging* ; Carbolines / metabolism* ; Cerebral Amyloid Angiopathy / diagnostic imaging* ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Positron-Emission Tomography* ; Thiazoles / metabolism
Keywords
18F-AV-1451 PET ; Cerebral amyloid angiopathy ; cortical superficial siderosis ; lobar cerebral microbleeds ; tau
Abstract
Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11C-Pittsburgh Compound B (PiB) PET or 18F-florbetaben PET to evaluate amyloid burden, and 18F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad161139
DOI
10.3233/JAD-161139
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179867
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links