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Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study

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dc.contributor.author김용배-
dc.date.accessioned2020-11-05T07:21:16Z-
dc.date.available2020-11-05T07:21:16Z-
dc.date.issued2019-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179825-
dc.description.abstractThis study evaluated the clinical significance of the lymph-node ratio (LNR) and its usefulness as an indicator of supraclavicular lymph-node radiation therapy (SCNRT) in pN1 breast cancer patients with disease-free survival (DFS) outcomes. We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). We compared their DFS according to LNR, with a cut-off value of 0.10. The median follow-up period was 66 months (range, 3-112). Treatment failed in 73 patients (6.5%) and there was no significant difference in DFS between the SCNRT group and non-SCNRT group. High LNR (>0.10) showed significantly worse DFS in both univariate and multivariate analyses (0.010 and 0.033, respectively). In a subgroup analysis, the effect of SCNRT on DFS differed significantly among patients with LNR > 0.10 (p = 0.013). High LNR can be used as an independent prognostic factor for pN1 breast cancer patients treated with partial mastectomy and postoperative radiotherapy. It may also be useful in deciding whether to perform SCNRT to improve DFS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJaeho Kim-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorDoo Ho Choi-
dc.contributor.googleauthorYeon-Joo Kim-
dc.contributor.googleauthorEun Sook Lee-
dc.contributor.googleauthorKyung Hwan Shin-
dc.contributor.googleauthorJin Ho Kim-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorSung-Ja Ahn-
dc.contributor.googleauthorJong Hoon Lee-
dc.contributor.googleauthorMison Chun-
dc.contributor.googleauthorHyung-Sik Lee-
dc.contributor.googleauthorJung Soo Kim-
dc.contributor.googleauthorJihye Cha-
dc.identifier.doi10.3390/cancers11050680-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid31100839-
dc.subject.keywordbreast cancer-
dc.subject.keyworddisease-free survival-
dc.subject.keywordlymph-node ratio-
dc.subject.keywordradiotherapy-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthor김용배-
dc.citation.volume11-
dc.citation.number5-
dc.citation.startPage680-
dc.identifier.bibliographicCitationCANCERS, Vol.11(5) : 680, 2019-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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