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Impact of Regional Nodal Irradiation for Breast Cancer Patients with Supraclavicular and/or Internal Mammary Lymph Node Involvement: A Multicenter, Retrospective Study (KROG 16-14)

DC FieldValueLanguage
dc.contributor.author서창옥-
dc.contributor.author김용배-
dc.date.accessioned2020-11-05T07:21:04Z-
dc.date.available2020-11-05T07:21:04Z-
dc.date.issued2019-10-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179823-
dc.description.abstractPurpose: The purpose of this study was to evaluate the treatment outcomes of radiotherapy (RT) for breast cancer with ipsilateral supraclavicular (SCL) and/or internal mammary (IMN) lymph node involvement. Materials and methods: A total of 353 patients from 11 institutions were included. One hundred and thirty-six patients had SCL involvement, 148 had IMN involvement, and 69 had both. All patients received neoadjuvant systemic therapy followed by breast-conserving surgery or mastectomy, and postoperative RT to whole breast/chest wall. As for regional lymph node irradiation, SCL RT was given to 344 patients, and IMN RT to 236 patients. The median RT dose was 50.4 Gy. Results: The median follow-up duration was 61 months (range, 7 to 173 months). In-field progression was present in SCL (n=20) and/or IMN (n=7). The 5-year disease-free survival (DFS) and overall survival rates were 57.8% and 75.1%, respectively. On multivariate analysis, both SCL/IMN involvement, number of axillary lymph node ≥ 4, triple-negative subtype, and mastectomy were significant adverse prognosticators for DFS (p=0.022, p=0.001, p=0.001, and p=0.004, respectively). Regarding the impact of regional nodal irradiation, SCL RT dose ≥ 54 Gy was not associated with DFS (5-year rate, 52.9% vs. 50.9%; p=0.696) in SCL-involved patients, and the receipt of IMN RT was not associated with DFS (5-year rate, 56.1% vs. 78.1%; p=0.099) in IMN-involved patients. Conclusion: Neoadjuvant chemotherapy followed by surgery and postoperative RT achieved an acceptable in-field regional control rate in patients with SCL and/or IMN involvement. However, a higher RT dose to SCL or IMN RT was not associated with the improved DFS in these patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBreast-
dc.subject.MESHBreast Neoplasms / radiotherapy*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHClavicle-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes / pathology*-
dc.subject.MESHLymphatic Metastasis / pathology-
dc.subject.MESHLymphatic Metastasis / radiotherapy*-
dc.subject.MESHMastectomy-
dc.subject.MESHMastectomy, Segmental-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleImpact of Regional Nodal Irradiation for Breast Cancer Patients with Supraclavicular and/or Internal Mammary Lymph Node Involvement: A Multicenter, Retrospective Study (KROG 16-14)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorYuri Jeong-
dc.contributor.googleauthorKyung Hwan Shin-
dc.contributor.googleauthorJin Ho Kim-
dc.contributor.googleauthorSeung Do Ahn-
dc.contributor.googleauthorSu Ssan Kim-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorDoo Ho Choi-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorMison Chun-
dc.contributor.googleauthorDong Soo Lee-
dc.contributor.googleauthorSun Young Lee-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorHae Jin Park-
dc.contributor.googleauthorWonguen Jung-
dc.identifier.doi10.4143/crt.2018.575-
dc.contributor.localIdA01919-
dc.contributor.localIdA00744-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid30913866-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordInternal mammary lymph node-
dc.subject.keywordRadiotherapy-
dc.subject.keywordSupraclavicular lymph node-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.affiliatedAuthor서창옥-
dc.contributor.affiliatedAuthor김용배-
dc.contributor.affiliatedAuthor김용배-
dc.citation.volume51-
dc.citation.number4-
dc.citation.startPage1500-
dc.citation.endPage1508-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.51(4) : 1500-1508, 2019-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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