83 213

Cited 0 times in

Impact of Adjuvant Chemotherapy Completion on Oncologic Outcomes in ypTNMstage 2 Rectal Cancer Patients

DC Field Value Language
dc.contributor.author이강영-
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.date.accessioned2020-11-05T07:20:37Z-
dc.date.available2020-11-05T07:20:37Z-
dc.date.issued2019-12-
dc.identifier.issn2287-9714-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179821-
dc.description.abstractPurpose: Adjuvant chemotherapy (aCT) in rectal cancer patients who have undergone curative resection after neoadjuvant chemoradiation (nCRT) is controversial. We aimed to investigate the benefits of using aCT and the clinical impact of completing aCT in ypstage 2 rectal cancer patients. Methods: We retrospectively reviewed clinicopathological data from patients who had undergone radical resection after nCRT between January 2006 and December 2012. In total, 152 patients with ypT3/4N0M0 rectal cancer were included. Of these patients, 139 initiated aCT, while 13 did not receive aCT (no-aCT). Among those who received aCT, 132 patients completed their planned cycles (aCT-completion) whereas 7 did not (aCT-incompletion). All patients received longcourse chemoradiation; a 5-fluorouracil-based regimen was used for nCRT in most patients. The prognostic factors affecting disease-free survival (DFS) and overall survival (OS) were analyzed. Results: The median follow-up duration was 41 months. Demographic data did not differ significantly among the 3 groups. In multivariate analysis, open surgery, a tumor size >2 cm, retrieval of <12 lymph nodes, circumferential resection margin (CRM) positivity and aCT incompletion were independent prognostic factors for poor DFS. Old age (≥60 years), open surgery, CRM positivity, aCT incompletion, and lack of aCT initiation compared to aCT completion were independent prognostic factors for poor OS. Conclusion: In ypstage 2 rectal cancer patients, aCT after nCRT and total mesorectal excision affected both DFS and OS; however, only patients who completed planned aCT exhibited survival benefits. Therefore, improving patients' compliance with the completion of aCT is desirable.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Coloproctology-
dc.relation.isPartOfANNALS OF COLOPROCTOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImpact of Adjuvant Chemotherapy Completion on Oncologic Outcomes in ypTNMstage 2 Rectal Cancer Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYoun Young Park-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorSat Byol Lee-
dc.contributor.googleauthorGa Ram Kim-
dc.contributor.googleauthorByung Soh Min-
dc.contributor.googleauthorSeong-Taek Oh-
dc.identifier.doi10.3393/ac.2019.03.10-
dc.contributor.localIdA02640-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.relation.journalcodeJ00157-
dc.identifier.eissn2287-9722-
dc.identifier.pmid31937073-
dc.subject.keywordAdjuvant chemotherap-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordNeoadjuvant therapy-
dc.subject.keywordRectal neoplasm-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor민병소-
dc.citation.volume35-
dc.citation.number6-
dc.citation.startPage335-
dc.citation.endPage341-
dc.identifier.bibliographicCitationANNALS OF COLOPROCTOLOGY, Vol.35(6) : 335-341, 2019-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.