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Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model

Authors
 Jun Young Park  ;  Ga Eul Chu  ;  Sanghyo Park  ;  Chaewon Park  ;  Susmita Aryal  ;  Won Jun Kang  ;  Won Gil Cho  ;  Jaehong Key 
Citation
 PHARMACEUTICS, Vol.12(8) : 739, 2020-08 
Journal Title
 PHARMACEUTICS 
Issue Date
2020-08
Keywords
asthma ; curcumin ; discoidal polymeric particle ; drug delivery system ; microparticle
Abstract
Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-co-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 μm and a zeta potential value of -34.6 ± 4.8 mV. Ex vivo biodistribution results showed that the Cur-PLGA-DPPs mainly accumulated in the lungs and liver after intravenous injection. Treatment with Cur-PLGA-DPPs effectively suppressed the infiltration of inflammatory cells in bronchoalveolar lavage fluid, and reduced bronchial wall thickening and goblet-cell hyperplasia compared to those in the phosphate-buffered-saline-treated control group. No significant changes in hematology and blood biochemistry parameters were observed after treatment with Cur-PLGA-DPPs. At equal curcumin concentrations, treatment with Cur-PLGA-DPPs exhibited better therapeutic efficacy than treatment with free curcumin. Our results suggest that the microscale Cur-PLGA-DPPs can be potentially used as a lung-targeted asthma therapy.
Files in This Item:
T9992020018.pdf Download
DOI
10.3390/pharmaceutics12080739
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Park, Jun Young(박준영) ORCID logo https://orcid.org/0000-0003-3403-2767
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179782
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