Cited 11 times in
Association of Longitudinal Trajectories of Systolic BP with Risk of Incident CKD: Results from the Korean Genome and Epidemiology Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 이창현 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 주영수 | - |
dc.date.accessioned | 2020-10-05T01:01:26Z | - |
dc.date.available | 2020-10-05T01:01:26Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179726 | - |
dc.description.abstract | Background: Although hypertension is a well known risk factor for CKD, few studies have evaluated the association between temporal trends of systolic BP and kidney function decline in persons without hypertension. Methods: We studied whether changes in systolic BP over time could influence incident CKD development in 4643 individuals without CKD and hypertension participating in the Korean Genome and Epidemiology Study, a prospective community-based cohort study. Using group-based trajectory modeling, we categorized three distinct systolic BP trajectories: decreasing, stable, and increasing. The primary outcome was incident CKD development, defined as two consecutive eGFR measurements <60 ml/min per 1.73 m2. Results: Among participants with an increasing systolic BP trajectory, systolic BP increased from 105 to 124 mm Hg. During 31,936 person-years of follow-up (median 7.7 years), 339 participants developed incident CKD. CKD incidence rates were 8.9, 9.6, and 17.8 cases per 1000 person-years in participants with decreasing, stable, and increasing systolic BP trajectories, respectively. In multivariable cause-specific Cox analysis, after adjustment of baseline eGFR, systolic BP, and other confounders, increasing systolic BP trajectory associated with a 1.57-fold higher risk of incident CKD (95% confidence interval, 1.20 to 2.06) compared with a stable trajectory. There was a significant effect modification of baseline systolic BP on the association between systolic BP trajectories and CKD risk (P value for interaction =0.02), and this association was particularly evident in participants with baseline systolic BP <120 mm Hg. In addition, increasing systolic BP trajectory versus a stable trajectory was associated with higher risk of new development of albuminuria. Conclusions: Increasing systolic BP over time without reaching the hypertension threshold is associated with a significantly increased risk of incident CKD in healthy adults. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Society of Nephrology | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of Longitudinal Trajectories of Systolic BP with Risk of Incident CKD: Results from the Korean Genome and Epidemiology Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Changhyun Lee | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Jonghyun Jhee | - |
dc.contributor.googleauthor | Hae-Ryong Yun | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1681/ASN.2020010084 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A05656 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J01779 | - |
dc.identifier.eissn | 1533-3450 | - |
dc.identifier.pmid | 32759227 | - |
dc.identifier.url | https://jasn.asnjournals.org/content/31/9/2133.long | - |
dc.subject.keyword | CKD development | - |
dc.subject.keyword | blood pressure | - |
dc.subject.keyword | blood pressure trend | - |
dc.subject.keyword | prehypertension | - |
dc.contributor.alternativeName | Yun, Hae Ryong | - |
dc.contributor.affiliatedAuthor | 윤해룡 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 이창현 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2133 | - |
dc.citation.endPage | 2144 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol.31(9) : 2133-2144, 2020-08 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.