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Early reduction of regulatory T cells is associated with acute rejection in liver transplantation under tacrolimus-based immunosuppression with basiliximab induction

DC Field Value Language
dc.contributor.author김종훈-
dc.contributor.author박준용-
dc.contributor.author박혜정-
dc.contributor.author이재근-
dc.contributor.author김순일-
dc.contributor.author김명수-
dc.contributor.author주동진-
dc.date.accessioned2020-10-05T01:00:17Z-
dc.date.available2020-10-05T01:00:17Z-
dc.date.issued2020-08-
dc.identifier.issn1600-6135-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179721-
dc.description.abstractRegulatory T (Treg) cells are important in preventing acute rejection (AR) in solid organ transplantation, but the clinical relevance of the different kinetics early after liver transplantation (LT) in acute rejectors and non-rejectors is unclear. We analyzed peripheral blood samples of 128 LT recipients receiving basiliximab induction plus tacrolimus immunosuppression. Samples were obtained at pretransplant, D7, and D30 after LT. Frequency and phenotype of Tregs were analyzed by flow cytometry. The predictive value of Treg frequency at D7 was assessed for suspected acute rejection (SAR) and was validated for biopsy-proven AR (BPAR). We found that the frequencies of total and activated Tregs at D7 were significantly lower in recipients with SAR and BPAR. Treg was more reduced in BPARs by in vitro tacrolimus treatment in the presence of basiliximab. Moreover, an early reduction of Treg frequency in rejectors was associated with a greater increase in Treg apoptosis and further attenuated IL-2 signaling. D7 Treg frequency was an independent risk factor for SAR, which was also validated for BPAR. In conclusion, first-week peripheral blood Treg frequency correlates with AR after LT under tacrolimus-based immunosuppression, which needs to be proven in larger, geographically and clinically diverse populations.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfAMERICAN JOURNAL OF TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEarly reduction of regulatory T cells is associated with acute rejection in liver transplantation under tacrolimus-based immunosuppression with basiliximab induction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorJi Won Han-
dc.contributor.googleauthorDong Jin Joo-
dc.contributor.googleauthorJong Hoon Kim-
dc.contributor.googleauthorMin-Seok Rha-
dc.contributor.googleauthorJune Young Koh-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorEui-Cheol Shin-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSu-Hyung Park-
dc.identifier.doi10.1111/ajt.15789-
dc.contributor.localIdA05233-
dc.contributor.localIdA01675-
dc.contributor.localIdA01769-
dc.contributor.localIdA03068-
dc.contributor.localIdA00649-
dc.contributor.localIdA00424-
dc.contributor.localIdA03948-
dc.relation.journalcodeJ00121-
dc.identifier.eissn1600-6143-
dc.identifier.pmid31965710-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/ajt.15789-
dc.subject.keywordimmunobiology-
dc.subject.keywordimmunosuppressant - calcineurin inhibitor (CNI)-
dc.subject.keywordimmunosuppression/immune modulation-
dc.subject.keywordliver transplantation/hepatology-
dc.subject.keywordlymphocyte biology-
dc.subject.keywordrejection-
dc.subject.keywordacute-
dc.subject.keywordtranslational research/science-
dc.contributor.alternativeNameKim, Jong Hoon-
dc.contributor.affiliatedAuthor김종훈-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박혜정-
dc.contributor.affiliatedAuthor이재근-
dc.contributor.affiliatedAuthor김순일-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor주동진-
dc.citation.volume20-
dc.citation.number8-
dc.citation.startPage2058-
dc.citation.endPage2069-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF TRANSPLANTATION, Vol.20(8) : 2058-2069, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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