0 183

Cited 0 times in

Clinical value of full-length tryptophanyl-tRNA synthetase for sepsis detection in critically ill patients - A retrospective clinical assessment

DC Field Value Language
dc.contributor.author윤보라-
dc.contributor.author박무석-
dc.contributor.author임아영-
dc.contributor.author이수환-
dc.contributor.author김영삼-
dc.contributor.author정경수-
dc.contributor.author최지수-
dc.contributor.author박무석-
dc.contributor.author임아영-
dc.contributor.author이수환-
dc.contributor.author김영삼-
dc.contributor.author정경수-
dc.contributor.author최지수-
dc.date.accessioned2020-10-04T16:52:13Z-
dc.date.available2020-10-04T16:52:13Z-
dc.date.issued2020-08-
dc.identifier.issn1201-9712-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179699-
dc.description.abstractObjectives: Related innate immune system activation and diagnostic factors of sepsis are not fully understood. The aim of this study was to analyze the clinical value of full-length tryptophanyl-tRNA synthetase (WRS) induced through inflammatory stimuli for the detection of sepsis and prediction of mortality in critically ill patients. Methods: This was a retrospective analysis of blood samples collected prospectively from patients in the medical intensive care unit (ICU) at Yonsei University College of Medicine, from March 2015 to June 2018. The ability of WRS to detect sepsis and predict mortality were compared to those of procalcitonin (PCT), C-reactive protein (CRP), and interleukin 6 (IL-6), and with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. Results: A total of 241 study patients were enrolled, of whom 190 (78.8%) had been diagnosed with sepsis on ICU admission. The areas under the receiver operating characteristics curves (AUROCs) for sepsis discrimination with WRS, PCT, CRP, and IL-6 levels, and SOFA and APACHE II scores were 0.864, 0.727, 0.625, 0.651, 0.840, and 0.754, respectively. The prediction of 28-day mortality in patients with sepsis using WRS levels was possible and non-inferior to that with the SOFA score. Conclusions: WRS secreted early in sepsis may be useful not only for the early detection of sepsis, but also for the prediction of mortality in critically ill patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical value of full-length tryptophanyl-tRNA synthetase for sepsis detection in critically ill patients - A retrospective clinical assessment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJi Soo Choi-
dc.contributor.googleauthorBo Ra Yoon-
dc.contributor.googleauthorJu Hye Shin-
dc.contributor.googleauthorSu Hwan Lee-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorKyung Soo Chung-
dc.identifier.doi10.1016/j.ijid.2020.05.105-
dc.contributor.localIdA02553-
dc.contributor.localIdA01457-
dc.contributor.localIdA01457-
dc.contributor.localIdA03382-
dc.contributor.localIdA03382-
dc.contributor.localIdA02904-
dc.contributor.localIdA02904-
dc.contributor.localIdA00707-
dc.contributor.localIdA00707-
dc.contributor.localIdA03570-
dc.contributor.localIdA03570-
dc.contributor.localIdA05057-
dc.contributor.localIdA05057-
dc.contributor.localIdA01457-
dc.contributor.localIdA01457-
dc.contributor.localIdA03382-
dc.contributor.localIdA03382-
dc.contributor.localIdA02904-
dc.contributor.localIdA02904-
dc.contributor.localIdA00707-
dc.contributor.localIdA00707-
dc.contributor.localIdA03570-
dc.contributor.localIdA03570-
dc.contributor.localIdA05057-
dc.contributor.localIdA05057-
dc.relation.journalcodeJ01125-
dc.identifier.eissn1878-3511-
dc.identifier.pmid32497803-
dc.identifier.urlhttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1201971220304124-
dc.subject.keywordIntensive care unit-
dc.subject.keywordMortality-
dc.subject.keywordSepsis-
dc.subject.keywordTryptophanyl-tRNA synthetase-
dc.contributor.alternativeNameYoon, Bo Ra-
dc.contributor.affiliatedAuthor윤보라-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor최지수-
dc.contributor.affiliatedAuthor최지수-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor최지수-
dc.contributor.affiliatedAuthor최지수-
dc.citation.volume97-
dc.citation.startPage260-
dc.citation.endPage266-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.97 : 260-266, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.