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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

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dc.contributor.author김한상-
dc.date.accessioned2020-10-04T16:50:46Z-
dc.date.available2020-10-04T16:50:46Z-
dc.date.issued2020-08-
dc.identifier.issn0092-8674-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179692-
dc.description.abstractThere is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n = 151) and plasma-derived (n = 120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer. Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleExtracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorAyuko Hoshino-
dc.contributor.googleauthorHan Sang Kim-
dc.contributor.googleauthorLinda Bojmar-
dc.contributor.googleauthorKofi Ennu Gyan-
dc.contributor.googleauthorMichele Cioffi-
dc.contributor.googleauthorJonathan Hernandez-
dc.contributor.googleauthorConstantinos P Zambirinis-
dc.contributor.googleauthorGonçalo Rodrigues-
dc.contributor.googleauthorHenrik Molina-
dc.contributor.googleauthorSøren Heissel-
dc.contributor.googleauthorMilica Tesic Mark-
dc.contributor.googleauthorLoïc Steiner-
dc.contributor.googleauthorAlberto Benito-Martin-
dc.contributor.googleauthorSerena Lucotti-
dc.contributor.googleauthorAngela Di Giannatale-
dc.contributor.googleauthorKatharine Offer-
dc.contributor.googleauthorMiho Nakajima-
dc.contributor.googleauthorCaitlin Williams-
dc.contributor.googleauthorLaura Nogués-
dc.contributor.googleauthorFanny A Pelissier Vatter-
dc.contributor.googleauthorAyako Hashimoto-
dc.contributor.googleauthorAlexander E Davies-
dc.contributor.googleauthorDaniela Freitas-
dc.contributor.googleauthorCandia M Kenific-
dc.contributor.googleauthorYonathan Ararso-
dc.contributor.googleauthorWeston Buehring-
dc.contributor.googleauthorPernille Lauritzen-
dc.contributor.googleauthorYusuke Ogitani-
dc.contributor.googleauthorKei Sugiura-
dc.contributor.googleauthorNaoko Takahashi-
dc.contributor.googleauthorMaša Alečković-
dc.contributor.googleauthorKayleen A Bailey-
dc.contributor.googleauthorJoshua S Jolissant-
dc.contributor.googleauthorHuajuan Wang-
dc.contributor.googleauthorAshton Harris-
dc.contributor.googleauthorL Miles Schaeffer-
dc.contributor.googleauthorGuillermo García-Santos-
dc.contributor.googleauthorZoe Posner-
dc.contributor.googleauthorVinod P Balachandran-
dc.contributor.googleauthorYasmin Khakoo-
dc.contributor.googleauthorG Praveen Raju-
dc.contributor.googleauthorAvigdor Scherz-
dc.contributor.googleauthorIrit Sagi-
dc.contributor.googleauthorRuth Scherz-Shouval-
dc.contributor.googleauthorYosef Yarden-
dc.contributor.googleauthorMoshe Oren-
dc.contributor.googleauthorMahathi Malladi-
dc.contributor.googleauthorMary Petriccione-
dc.contributor.googleauthorKevin C De Braganca-
dc.contributor.googleauthorMaria Donzelli-
dc.contributor.googleauthorCheryl Fischer-
dc.contributor.googleauthorStephanie Vitolano-
dc.contributor.googleauthorGeraldine P Wright-
dc.contributor.googleauthorLee Ganshaw-
dc.contributor.googleauthorMariel Marrano-
dc.contributor.googleauthorAmina Ahmed-
dc.contributor.googleauthorJoe DeStefano-
dc.contributor.googleauthorEnrico Danzer-
dc.contributor.googleauthorMichael H A Roehrl-
dc.contributor.googleauthorNorman J Lacayo-
dc.contributor.googleauthorTheresa C Vincent-
dc.contributor.googleauthorMartin R Weiser-
dc.contributor.googleauthorMary S Brady-
dc.contributor.googleauthorPaul A Meyers-
dc.contributor.googleauthorLeonard H Wexler-
dc.contributor.googleauthorSrikanth R Ambati-
dc.contributor.googleauthorAlexander J Chou-
dc.contributor.googleauthorEmily K Slotkin-
dc.contributor.googleauthorShakeel Modak-
dc.contributor.googleauthorStephen S Roberts-
dc.contributor.googleauthorEllen M Basu-
dc.contributor.googleauthorDaniel Diolaiti-
dc.contributor.googleauthorBenjamin A Krantz-
dc.contributor.googleauthorFatima Cardoso-
dc.contributor.googleauthorAmber L Simpson-
dc.contributor.googleauthorMichael Berger-
dc.contributor.googleauthorCharles M Rudin-
dc.contributor.googleauthorDiane M Simeone-
dc.contributor.googleauthorManeesh Jain-
dc.contributor.googleauthorCyrus M Ghajar-
dc.contributor.googleauthorSurinder K Batra-
dc.contributor.googleauthorBen Z Stanger-
dc.contributor.googleauthorJack Bui-
dc.contributor.googleauthorKristy A Brown-
dc.contributor.googleauthorVinagolu K Rajasekhar-
dc.contributor.googleauthorJohn H Healey-
dc.contributor.googleauthorMaria de Sousa-
dc.contributor.googleauthorKim Kramer-
dc.contributor.googleauthorSujit Sheth-
dc.contributor.googleauthorJeanine Baisch-
dc.contributor.googleauthorVirginia Pascual-
dc.contributor.googleauthorTodd E Heaton-
dc.contributor.googleauthorMichael P La Quaglia-
dc.contributor.googleauthorDavid J Pisapia-
dc.contributor.googleauthorRobert Schwartz-
dc.contributor.googleauthorHaiying Zhang-
dc.contributor.googleauthorYuan Liu-
dc.contributor.googleauthorArti Shukla-
dc.contributor.googleauthorLaurence Blavier-
dc.contributor.googleauthorYves A DeClerck-
dc.contributor.googleauthorMark LaBarge-
dc.contributor.googleauthorMina J Bissell-
dc.contributor.googleauthorThomas C Caffrey-
dc.contributor.googleauthorPaul M Grandgenett-
dc.contributor.googleauthorMichael A Hollingsworth-
dc.contributor.googleauthorJacqueline Bromberg-
dc.contributor.googleauthorBruno Costa-Silva-
dc.contributor.googleauthorHector Peinado-
dc.contributor.googleauthorYibin Kang-
dc.contributor.googleauthorBenjamin A Garcia-
dc.contributor.googleauthorEileen M O'Reilly-
dc.contributor.googleauthorDavid Kelsen-
dc.contributor.googleauthorTanya M Trippett-
dc.contributor.googleauthorDavid R Jones-
dc.contributor.googleauthorIrina R Matei-
dc.contributor.googleauthorWilliam R Jarnagin-
dc.contributor.googleauthorDavid Lyden-
dc.identifier.doi10.1016/j.cell.2020.07.009-
dc.contributor.localIdA01098-
dc.relation.journalcodeJ00472-
dc.identifier.eissn1097-4172-
dc.identifier.pmid32795414-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0092867420308746-
dc.subject.keywordbiomarkers-
dc.subject.keywordcancer-
dc.subject.keywordcancer of unknown primary origin-
dc.subject.keyworddamage-associated molecular patterns-
dc.subject.keywordearly cancer detection-
dc.subject.keywordexomeres-
dc.subject.keywordexosomes-
dc.subject.keywordextracellular vesicles and particles-
dc.subject.keywordliquid biopsy-
dc.subject.keywordproteomics-
dc.contributor.alternativeNameKim, Han Sang-
dc.contributor.affiliatedAuthor김한상-
dc.citation.volume182-
dc.citation.number4-
dc.citation.startPage1044-
dc.citation.endPage1061.e18-
dc.identifier.bibliographicCitationCELL, Vol.182(4) : 1044-1061.e18, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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