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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

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dc.contributor.authorHoshino, Ayuko-
dc.contributor.authorKim, Han Sang-
dc.contributor.authorBojmar, Linda-
dc.contributor.authorGyan, Kofi Ennu-
dc.contributor.authorCioffi, Michele-
dc.contributor.authorHernandez, Jonathan-
dc.contributor.authorZambirinis, Constantinos P.-
dc.contributor.authorRodrigues, Goncalo-
dc.contributor.authorMolina, Henrik-
dc.contributor.authorHeissel, Sren-
dc.contributor.authorMark, Milica Tesic-
dc.contributor.authorSteiner, Loic-
dc.contributor.authorBenito-Martin, Alberto-
dc.contributor.authorLucotti, Serena-
dc.contributor.authorDi Giannatale, Angela-
dc.contributor.authorOffer, Katharine-
dc.contributor.authorNakajima, Miho-
dc.contributor.authorWilliams, Caitlin-
dc.contributor.authorNogues, Laura-
dc.contributor.authorVatter, Fanny A. Pelissier-
dc.contributor.authorHashimoto, Ayako-
dc.contributor.authorDavies, Alexander E.-
dc.contributor.authorFreitas, Daniela-
dc.contributor.authorKenific, Candia M.-
dc.contributor.authorArarso, Yonathan-
dc.contributor.authorBuehring, Weston-
dc.contributor.authorLauritzen, Pernille-
dc.contributor.authorOgitani, Yusuke-
dc.contributor.authorSugiura, Kei-
dc.contributor.authorTakahashi, Naoko-
dc.contributor.authorAleckovic, Masa-
dc.contributor.authorBailey, Kayleen A.-
dc.contributor.authorJolissant, Joshua S.-
dc.contributor.authorWang, Huajuan-
dc.contributor.authorHarris, Ashton-
dc.contributor.authorSchaeffer, L. Miles-
dc.contributor.authorGarcia-Santos, Guillermo-
dc.contributor.authorPosner, Zoe-
dc.contributor.authorBalachandran, Vinod P.-
dc.contributor.authorKhakoo, Yasmin-
dc.contributor.authorRaju, G. Praveen-
dc.contributor.authorScherz, Avigdor-
dc.contributor.authorSagi, Irit-
dc.contributor.authorScherz-Shouval, Ruth-
dc.contributor.authorYarden, Yosef-
dc.contributor.authorOren, Moshe-
dc.contributor.authorMalladi, Mahathi-
dc.contributor.authorPetriccione, Mary-
dc.contributor.authorDe Braganca, Kevin C.-
dc.contributor.authorDonzelli, Maria-
dc.contributor.authorFischer, Cheryl-
dc.contributor.authorVitolano, Stephanie-
dc.contributor.authorWright, Geraldine P.-
dc.contributor.authorGanshaw, Lee-
dc.contributor.authorMarrano, Mariel-
dc.contributor.authorAhmed, Amina-
dc.contributor.authorDeStefano, Joe-
dc.contributor.authorDanzer, Enrico-
dc.contributor.authorRoehrl, Michael H. A.-
dc.contributor.authorLacayo, Norman J.-
dc.contributor.authorVincent, Theresa C.-
dc.contributor.authorWeiser, Martin R.-
dc.contributor.authorBrady, Mary S.-
dc.contributor.authorMeyers, Paul A.-
dc.contributor.authorWexler, Leonard H.-
dc.contributor.authorAmbati, Srikanth R.-
dc.contributor.authorChou, Alexander J.-
dc.contributor.authorSlotkin, Emily K.-
dc.contributor.authorModak, Shakeel-
dc.contributor.authorRoberts, Stephen S.-
dc.contributor.authorBasu, Ellen M.-
dc.contributor.authorDiolaiti, Daniel-
dc.contributor.authorKrantz, Benjamin A.-
dc.contributor.authorCardoso, Fatima-
dc.contributor.authorSimpson, Amber L.-
dc.contributor.authorBerger, Michael-
dc.contributor.authorRudin, Charles M.-
dc.contributor.authorSimeone, Diane M.-
dc.contributor.authorJain, Maneesh-
dc.contributor.authorGhajar, Cyrus M.-
dc.contributor.authorBatra, Surinder K.-
dc.contributor.authorStanger, Ben Z.-
dc.contributor.authorBui, Jack-
dc.contributor.authorBrown, Kristy A.-
dc.contributor.authorRajasekhar, Vinagolu K.-
dc.contributor.authorHealey, John H.-
dc.contributor.authorde Sousa, Maria-
dc.contributor.authorKramer, Kim-
dc.contributor.authorSheth, Sujit-
dc.contributor.authorBaisch, Jeanine-
dc.contributor.authorPascual, Virginia-
dc.contributor.authorHeaton, Todd E.-
dc.contributor.authorLa Quaglia, Michael P.-
dc.contributor.authorPisapia, David J.-
dc.contributor.authorSchwartz, Robert-
dc.contributor.authorZhang, Haiying-
dc.contributor.authorLiu, Yuan-
dc.contributor.authorShukla, Arti-
dc.contributor.authorBlavier, Laurence-
dc.contributor.authorDeClerck, Yves A.-
dc.contributor.authorLaBarge, Mark-
dc.contributor.authorBissell, Mina J.-
dc.contributor.authorCaffrey, Thomas C.-
dc.contributor.authorGrandgenett, Paul M.-
dc.contributor.authorHollingsworth, Michael A.-
dc.contributor.authorBromberg, Jacqueline-
dc.contributor.authorCosta-Silva, Bruno-
dc.contributor.authorPeinado, Hector-
dc.contributor.authorKang, Yibin-
dc.contributor.authorGarcia, Benjamin A.-
dc.contributor.authorO'Reilly, Eileen M.-
dc.contributor.authorKelsen, David-
dc.contributor.authorTrippett, Tanya M.-
dc.contributor.authorJones, David R.-
dc.contributor.authorMatei, Irina R.-
dc.contributor.authorJarnagin, William R.-
dc.contributor.authorLyden, David-
dc.date.accessioned2020-10-04T16:50:46Z-
dc.date.available2020-10-04T16:50:46Z-
dc.date.created2021-03-18-
dc.date.issued2020-08-
dc.identifier.issn0092-8674-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179692-
dc.description.abstractThere is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n =151) and plasma-derived (n =120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCELL-
dc.relation.isPartOfCELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleExtracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHoshino, Ayuko-
dc.contributor.googleauthorKim, Han Sang-
dc.contributor.googleauthorBojmar, Linda-
dc.contributor.googleauthorGyan, Kofi Ennu-
dc.contributor.googleauthorCioffi, Michele-
dc.contributor.googleauthorHernandez, Jonathan-
dc.contributor.googleauthorZambirinis, Constantinos P.-
dc.contributor.googleauthorRodrigues, Goncalo-
dc.contributor.googleauthorMolina, Henrik-
dc.contributor.googleauthorHeissel, Sren-
dc.contributor.googleauthorMark, Milica Tesic-
dc.contributor.googleauthorSteiner, Loic-
dc.contributor.googleauthorBenito-Martin, Alberto-
dc.contributor.googleauthorLucotti, Serena-
dc.contributor.googleauthorDi Giannatale, Angela-
dc.contributor.googleauthorOffer, Katharine-
dc.contributor.googleauthorNakajima, Miho-
dc.contributor.googleauthorWilliams, Caitlin-
dc.contributor.googleauthorNogues, Laura-
dc.contributor.googleauthorVatter, Fanny A. Pelissier-
dc.contributor.googleauthorHashimoto, Ayako-
dc.contributor.googleauthorDavies, Alexander E.-
dc.contributor.googleauthorFreitas, Daniela-
dc.contributor.googleauthorKenific, Candia M.-
dc.contributor.googleauthorArarso, Yonathan-
dc.contributor.googleauthorBuehring, Weston-
dc.contributor.googleauthorLauritzen, Pernille-
dc.contributor.googleauthorOgitani, Yusuke-
dc.contributor.googleauthorSugiura, Kei-
dc.contributor.googleauthorTakahashi, Naoko-
dc.contributor.googleauthorAleckovic, Masa-
dc.contributor.googleauthorBailey, Kayleen A.-
dc.contributor.googleauthorJolissant, Joshua S.-
dc.contributor.googleauthorWang, Huajuan-
dc.contributor.googleauthorHarris, Ashton-
dc.contributor.googleauthorSchaeffer, L. Miles-
dc.contributor.googleauthorGarcia-Santos, Guillermo-
dc.contributor.googleauthorPosner, Zoe-
dc.contributor.googleauthorBalachandran, Vinod P.-
dc.contributor.googleauthorKhakoo, Yasmin-
dc.contributor.googleauthorRaju, G. Praveen-
dc.contributor.googleauthorScherz, Avigdor-
dc.contributor.googleauthorSagi, Irit-
dc.contributor.googleauthorScherz-Shouval, Ruth-
dc.contributor.googleauthorYarden, Yosef-
dc.contributor.googleauthorOren, Moshe-
dc.contributor.googleauthorMalladi, Mahathi-
dc.contributor.googleauthorPetriccione, Mary-
dc.contributor.googleauthorDe Braganca, Kevin C.-
dc.contributor.googleauthorDonzelli, Maria-
dc.contributor.googleauthorFischer, Cheryl-
dc.contributor.googleauthorVitolano, Stephanie-
dc.contributor.googleauthorWright, Geraldine P.-
dc.contributor.googleauthorGanshaw, Lee-
dc.contributor.googleauthorMarrano, Mariel-
dc.contributor.googleauthorAhmed, Amina-
dc.contributor.googleauthorDeStefano, Joe-
dc.contributor.googleauthorDanzer, Enrico-
dc.contributor.googleauthorRoehrl, Michael H. A.-
dc.contributor.googleauthorLacayo, Norman J.-
dc.contributor.googleauthorVincent, Theresa C.-
dc.contributor.googleauthorWeiser, Martin R.-
dc.contributor.googleauthorBrady, Mary S.-
dc.contributor.googleauthorMeyers, Paul A.-
dc.contributor.googleauthorWexler, Leonard H.-
dc.contributor.googleauthorAmbati, Srikanth R.-
dc.contributor.googleauthorChou, Alexander J.-
dc.contributor.googleauthorSlotkin, Emily K.-
dc.contributor.googleauthorModak, Shakeel-
dc.contributor.googleauthorRoberts, Stephen S.-
dc.contributor.googleauthorBasu, Ellen M.-
dc.contributor.googleauthorDiolaiti, Daniel-
dc.contributor.googleauthorKrantz, Benjamin A.-
dc.contributor.googleauthorCardoso, Fatima-
dc.contributor.googleauthorSimpson, Amber L.-
dc.contributor.googleauthorBerger, Michael-
dc.contributor.googleauthorRudin, Charles M.-
dc.contributor.googleauthorSimeone, Diane M.-
dc.contributor.googleauthorJain, Maneesh-
dc.contributor.googleauthorGhajar, Cyrus M.-
dc.contributor.googleauthorBatra, Surinder K.-
dc.contributor.googleauthorStanger, Ben Z.-
dc.contributor.googleauthorBui, Jack-
dc.contributor.googleauthorBrown, Kristy A.-
dc.contributor.googleauthorRajasekhar, Vinagolu K.-
dc.contributor.googleauthorHealey, John H.-
dc.contributor.googleauthorde Sousa, Maria-
dc.contributor.googleauthorKramer, Kim-
dc.contributor.googleauthorSheth, Sujit-
dc.contributor.googleauthorBaisch, Jeanine-
dc.contributor.googleauthorPascual, Virginia-
dc.contributor.googleauthorHeaton, Todd E.-
dc.contributor.googleauthorLa Quaglia, Michael P.-
dc.contributor.googleauthorPisapia, David J.-
dc.contributor.googleauthorSchwartz, Robert-
dc.contributor.googleauthorZhang, Haiying-
dc.contributor.googleauthorLiu, Yuan-
dc.contributor.googleauthorShukla, Arti-
dc.contributor.googleauthorBlavier, Laurence-
dc.contributor.googleauthorDeClerck, Yves A.-
dc.contributor.googleauthorLaBarge, Mark-
dc.contributor.googleauthorBissell, Mina J.-
dc.contributor.googleauthorCaffrey, Thomas C.-
dc.contributor.googleauthorGrandgenett, Paul M.-
dc.contributor.googleauthorHollingsworth, Michael A.-
dc.contributor.googleauthorBromberg, Jacqueline-
dc.contributor.googleauthorCosta-Silva, Bruno-
dc.contributor.googleauthorPeinado, Hector-
dc.contributor.googleauthorKang, Yibin-
dc.contributor.googleauthorGarcia, Benjamin A.-
dc.contributor.googleauthorO'Reilly, Eileen M.-
dc.contributor.googleauthorKelsen, David-
dc.contributor.googleauthorTrippett, Tanya M.-
dc.contributor.googleauthorJones, David R.-
dc.contributor.googleauthorMatei, Irina R.-
dc.contributor.googleauthorJarnagin, William R.-
dc.contributor.googleauthorLyden, David-
dc.identifier.doi10.1016/j.cell.2020.07.009-
dc.relation.journalcodeJ00472-
dc.identifier.eissn1097-4172-
dc.subject.keywordbiomarkers-
dc.subject.keywordcancer-
dc.subject.keywordcancer of unknown primary origin-
dc.subject.keyworddamage-associated molecular patterns-
dc.subject.keywordearly cancer detection-
dc.subject.keywordexomeres-
dc.subject.keywordexosomes-
dc.subject.keywordextracellular vesicles and particles-
dc.subject.keywordliquid biopsy-
dc.subject.keywordproteomics-
dc.contributor.alternativeNameKim, Han Sang-
dc.contributor.affiliatedAuthorKim, Han Sang-
dc.identifier.scopusid2-s2.0-85089433166-
dc.identifier.wosid000561488500021-
dc.citation.volume182-
dc.citation.number4-
dc.citation.startPage1044-
dc.citation.endPage+-
dc.identifier.bibliographicCitationCELL, Vol.182(4) : 1044-+, 2020-08-
dc.identifier.rimsid68983-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorbiomarkers-
dc.subject.keywordAuthorcancer-
dc.subject.keywordAuthorcancer of unknown primary origin-
dc.subject.keywordAuthordamage-associated molecular patterns-
dc.subject.keywordAuthorearly cancer detection-
dc.subject.keywordAuthorexomeres-
dc.subject.keywordAuthorexosomes-
dc.subject.keywordAuthorextracellular vesicles and particles-
dc.subject.keywordAuthorliquid biopsy-
dc.subject.keywordAuthorproteomics-
dc.subject.keywordPlusPLASMA-MEMBRANE-
dc.subject.keywordPlusEXOSOMES-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordPlusMETASTASIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusSTOMATIN-
dc.subject.keywordPlusGENES-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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