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Bicarbonate permeation through anion channels: its role in health and disease

Authors
 Dong Hoon Shin  ;  Minjae Kim  ;  Yonjung Kim  ;  Ikhyun Jun  ;  Jinsei Jung  ;  Joo Hyun Nam  ;  Mary Hongying Cheng  ;  Min Goo Lee 
Citation
 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol.472(8) : 1003-1018, 2020-08 
Journal Title
 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 
ISSN
 0031-6768 
Issue Date
2020-08
Keywords
Bicarbonate ; Chloride channel ; Epithelia ; Ion selectivity ; Neuron
Abstract
Many anion channels, frequently referred as Cl- channels, are permeable to different anions in addition to Cl-. As the second-most abundant anion in the human body, HCO3- permeation via anion channels has many important physiological roles. In addition to its classical role as an intracellular pH regulator, HCO3- also controls the activity and stability of dissolved proteins in bodily fluids such as saliva, pancreatic juice, intestinal fluid, and airway surface liquid. Moreover, HCO3- permeation through these channels affects membrane potentials that are the driving forces for transmembrane transport of solutes and water in epithelia and affect neuronal excitability in nervous tissue. Consequently, aberrant HCO3- transport via anion channels causes a number of human diseases in respiratory, gastrointestinal, genitourinary, and neuronal systems. Notably, recent studies have shown that the HCO3- permeabilities of several anion channels are not fixed and can be altered by cellular stimuli, findings which may have both physiological and pathophysiological significance. In this review, we summarize recent progress in understanding the molecular mechanisms and the physiological roles of HCO3- permeation through anion channels. We hope that the present discussions can stimulate further research into this very important topic, which will provide the basis for human disorders associated with aberrant HCO3- transport.
Full Text
https://link.springer.com/article/10.1007%2Fs00424-020-02425-x
DOI
10.1007/s00424-020-02425-x
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yon Jung(김연정) ORCID logo https://orcid.org/0000-0003-0251-8711
Shin, Dong Hoon(신동훈)
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Jun, Ik Hyun(전익현) ORCID logo https://orcid.org/0000-0002-2160-1679
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179683
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