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Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

DC Field Value Language
dc.contributor.author박은정-
dc.contributor.author백승혁-
dc.contributor.author백승혁-
dc.date.accessioned2020-10-04T16:47:59Z-
dc.date.available2020-10-04T16:47:59Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179672-
dc.description.abstractColorectal cancer with peritoneal metastasis has a poor prognosis because of inadequate responses to systemic chemotherapy. Cytoreductive surgery followed by intraperitoneal (IP) chemotherapy using oxaliplatin has attracted attention; however, the short half-life of oxaliplatin and its rapid clearance from the peritoneal cavity limit its clinical application. Here, a multivesicular liposomal (MVL) depot of oxaliplatin was prepared for IP administration, with an expected prolonged effect. After optimization, a combination of phospholipids, cholesterol, and triolein was used based on its ability to produce MVL depots of monomodal size distribution (1-20 µm; span 1.99) with high entrapment efficiency (EE) (92.16% ± 2.17%). An initial burst release followed by a long lag phase of drug release was observed for the MVL depots system in vitro. An in vivo pharmacokinetic study mimicking the early postoperative IP chemotherapy regimen in rats showed significantly improved bioavailability, and the mean residence time of oxaliplatin after IP administration revealed that slow and continuous erosion of the MVL particles yielded a sustained drug release. Thus, oxaliplatin-loaded MVL depots presented in this study have potential for use in the treatment of colorectal cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfPHARMACEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePreparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSharif Md Abuzar-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorYeji Seo-
dc.contributor.googleauthorJuseung Lee-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorSung-Joo Hwang-
dc.identifier.doi10.3390/pharmaceutics12080736-
dc.contributor.localIdA04572-
dc.contributor.localIdA01827-
dc.contributor.localIdA01827-
dc.contributor.localIdA01827-
dc.contributor.localIdA01827-
dc.relation.journalcodeJ02504-
dc.identifier.eissn1999-4923-
dc.identifier.pmid32764318-
dc.subject.keywordcolorectal cancer-
dc.subject.keyworddepot-
dc.subject.keywordearly postoperative intraperitoneal chemotherapy-
dc.subject.keywordmultivesicular liposome-
dc.subject.keywordoxaliplatin-
dc.subject.keywordsustained release-
dc.contributor.alternativeNamePark, Eun Jung-
dc.contributor.affiliatedAuthor박은정-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor백승혁-
dc.citation.volume12-
dc.citation.number8-
dc.citation.startPageE736-
dc.identifier.bibliographicCitationPHARMACEUTICS, Vol.12(8) : E736, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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