Cited 4 times in
Impact of vanA-Positive Enterococcus faecium Exhibiting Diverse Susceptibility Phenotypes to Glycopeptides on 30-Day Mortality of Patients with a Bloodstream Infection
DC Field | Value | Language |
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dc.contributor.author | 이혁민 | - |
dc.contributor.author | 김도균 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 윤은정 | - |
dc.contributor.author | 홍준성 | - |
dc.date.accessioned | 2020-09-30T16:44:35Z | - |
dc.date.available | 2020-09-30T16:44:35Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179603 | - |
dc.description.abstract | This study was performed to evaluate the impacts of vanA positivity of Enterococcus faecium exhibiting diverse susceptibility phenotypes to glycopeptides on clinical outcomes in patients with a bloodstream infection (BSI) through a prospective, multicenter, observational study. A total of 509 patients with E. faecium BSI from eight sentinel hospitals in South Korea during a 2-year period were enrolled in this study. Risk factors of the hosts and causative E. faecium isolates were assessed to determine associations with the 30-day mortality of E. faecium BSI patients via multivariable logistic regression analyses. The vanA gene was detected in 35.2% (179/509) of E. faecium isolates; 131 E. faecium isolates exhibited typical VanA phenotypes (group vanA-VanA), while the remaining 48 E. faecium isolates exhibited atypical phenotypes (group vanA-atypical), which included VanD (n = 43) and vancomycin-variable phenotypes (n = 5). A multivariable logistic regression indicated that vanA positivity of causative pathogens was independently associated with the increased 30-day mortality rate in the patients with E. faecium BSI; however, there was no significant difference in survival rates between the patients of the vanA-VanA and vanA-atypical groups (log rank test, P = 0.904). A high 30-day mortality rate was observed in patients with vanA-positive E. faecium BSIs, and vanA positivity of causative E. faecium isolates was an independent risk factor for early mortality irrespective of the susceptibility phenotypes to glycopeptides; thus, intensified antimicrobial stewardship is needed to improve the clinical outcomes of patients with vanA-positive E. faecium BSI. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Society for Microbiology | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Impact of vanA-Positive Enterococcus faecium Exhibiting Diverse Susceptibility Phenotypes to Glycopeptides on 30-Day Mortality of Patients with a Bloodstream Infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Eun-Jeong Yoon | - |
dc.contributor.googleauthor | Jun Sung Hong | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Kyeong Seob Shin | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Young Ree Kim | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.contributor.googleauthor | Yoon Soo Park | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.identifier.doi | 10.1128/AAC.02180-19 | - |
dc.contributor.localId | A03286 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00189 | - |
dc.identifier.eissn | 1098-6596 | - |
dc.identifier.pmid | 32340989 | - |
dc.identifier.url | https://aac.asm.org/content/64/7/e02180-19.long | - |
dc.subject.keyword | Enterococcus faecium | - |
dc.subject.keyword | VanD phenotype | - |
dc.subject.keyword | clinical outcome | - |
dc.subject.keyword | teicoplanin | - |
dc.subject.keyword | vancomycin | - |
dc.contributor.alternativeName | Lee, Hyuk Min | - |
dc.contributor.affiliatedAuthor | 이혁민 | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e02180-19 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.64(7) : e02180-19, 2020-07 | - |
dc.identifier.rimsid | 67180 | - |
dc.type.rims | ART | - |
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