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Synthesis of 18 F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination

DC FieldValueLanguage
dc.contributor.author유영훈-
dc.contributor.author전중현-
dc.contributor.author전중현-
dc.contributor.author전중현-
dc.contributor.author전중현-
dc.date.accessioned2020-09-30T16:43:25Z-
dc.date.available2020-09-30T16:43:25Z-
dc.date.issued2020-07-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179593-
dc.description.abstractSulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited 18F-radiochemistry translation, due to the inaccessibility of gaseous [18F]SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [18F]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced 18F-. The radiochemical yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [18F]fluorosulfate.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfORGANIC LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSynthesis of 18 F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorYoung-Do Kwon-
dc.contributor.googleauthorMin Ho Jeon-
dc.contributor.googleauthorNam Kyu Park-
dc.contributor.googleauthorJeong Kon Seo-
dc.contributor.googleauthorJeongmin Son-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorSung You Hong-
dc.contributor.googleauthorJoong-Hyun Chun-
dc.identifier.doi10.1021/acs.orglett.0c01868-
dc.contributor.localIdA02485-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.contributor.localIdA05406-
dc.relation.journalcodeJ03589-
dc.identifier.eissn1523-7052-
dc.identifier.pmid32589035-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.orglett.0c01868-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor전중현-
dc.citation.volume22-
dc.citation.number14-
dc.citation.startPage5511-
dc.citation.endPage5516-
dc.identifier.bibliographicCitationORGANIC LETTERS, Vol.22(14) : 5511-5516, 2020-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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