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Synthesis of 18 F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination

Authors
 Young-Do Kwon  ;  Min Ho Jeon  ;  Nam Kyu Park  ;  Jeong Kon Seo  ;  Jeongmin Son  ;  Young Hoon Ryu  ;  Sung You Hong  ;  Joong-Hyun Chun 
Citation
 ORGANIC LETTERS, Vol.22(14) : 5511-5516, 2020-07 
Journal Title
 ORGANIC LETTERS 
ISSN
 1523-7060 
Issue Date
2020-07
Abstract
Sulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited 18F-radiochemistry translation, due to the inaccessibility of gaseous [18F]SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [18F]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced 18F-. The radiochemical yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [18F]fluorosulfate.
Full Text
https://pubs.acs.org/doi/10.1021/acs.orglett.0c01868
DOI
10.1021/acs.orglett.0c01868
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179593
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