Cited 19 times in
The contributing factors for lateral neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC)
DC Field | Value | Language |
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dc.contributor.author | 남기현 | - |
dc.contributor.author | 이잔디 | - |
dc.contributor.author | 이초록 | - |
dc.contributor.author | 김진경 | - |
dc.contributor.author | 강상욱 | - |
dc.contributor.author | 정종주 | - |
dc.contributor.author | 정웅윤 | - |
dc.date.accessioned | 2020-09-29T06:26:54Z | - |
dc.date.available | 2020-09-29T06:26:54Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179561 | - |
dc.description.abstract | Purpose: Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis due to its indolent features. Only few studies have assessed the clinical factors that can predict lateral neck lymph node metastasis (LLNM) in patients with PTMC. This study aimed to examine the clinicopathological factors associated with LLNM in patients with PTMC. Methods: We reviewed medical records of 3578 patients with PTMC that was ≤1 cm in diameter on final pathology at Yonsei University Hospital between January 2015 and December 2017. The patients were divided into two groups (metastasis group [n = 157] and no metastasis group [n = 3421]). Results: The proportion of patients with multifocality, extrathyroidal extension (ETE), and central node metastasis was significantly higher in metastasis group (p < 0.001, p < 0.001 and p < 0.001, respectively), and the mean tumor size was relatively larger in metastasis group than in no metastasis group (0.7 ± 0.2 vs. 0.6 ± 0.2 cm, p < 0.001). However, no statistically significant differences were observed in the tumors harboring BRAF mutation between the two groups (84.8% vs. 80.6%, p = 0.199). Multivariate analysis indicated that the significant risk factors of LLNM include ETE (odds ratio [OR]: 1.904, 95% confidence interval [CI]: 1.267-2.861), multifocality (OR: 2.255, 95% CI: 1.544-3.293), and central node metastasis (OR: 7.768, 95% CI: 4.869-12.395), but not BRAF mutation (OR: 0.542, 95% CI: 0.337-0.874). Conclusion: Approximately 4.4% of patients with PTMC presented with LLNM at the time of diagnosis. Moreover, the significant risk factors of LLNM include central node metastasis, ETE, and multifocal disease but not BRAF mutation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Humana Press | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The contributing factors for lateral neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Kwangsoon Kim | - |
dc.contributor.googleauthor | Xiaojin Zheng | - |
dc.contributor.googleauthor | Jin Kyong Kim | - |
dc.contributor.googleauthor | Cho Rok Lee | - |
dc.contributor.googleauthor | Sang-Wook Kang | - |
dc.contributor.googleauthor | Jandee Lee | - |
dc.contributor.googleauthor | Jong Ju Jeong | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.identifier.doi | 10.1007/s12020-020-02251-2 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A03066 | - |
dc.contributor.localId | A03256 | - |
dc.contributor.localId | A05739 | - |
dc.contributor.localId | A00032 | - |
dc.contributor.localId | A03722 | - |
dc.contributor.localId | A03674 | - |
dc.relation.journalcode | J00768 | - |
dc.identifier.eissn | 1559-0100 | - |
dc.identifier.pmid | 32146654 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12020-020-02251-2 | - |
dc.subject.keyword | BRAF | - |
dc.subject.keyword | Lateral neck lymph node metastasis | - |
dc.subject.keyword | Papillary thyroid carcinoma | - |
dc.subject.keyword | Papillary thyroid microcarcinoma | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | 남기현 | - |
dc.contributor.affiliatedAuthor | 이잔디 | - |
dc.contributor.affiliatedAuthor | 이초록 | - |
dc.contributor.affiliatedAuthor | 김진경 | - |
dc.contributor.affiliatedAuthor | 강상욱 | - |
dc.contributor.affiliatedAuthor | 정종주 | - |
dc.contributor.affiliatedAuthor | 정웅윤 | - |
dc.citation.volume | 69 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 156 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, Vol.69(1) : 149-156, 2020-07 | - |
dc.identifier.rimsid | 67175 | - |
dc.type.rims | ART | - |
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