Cited 3 times in
Glucose Loading Enhances the Value of 18 F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
DC Field | Value | Language |
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dc.contributor.author | 이용호 | - |
dc.contributor.author | 문주형 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이미수 | - |
dc.contributor.author | 김동우 | - |
dc.date.accessioned | 2020-09-29T04:52:41Z | - |
dc.date.available | 2020-09-29T04:52:41Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179525 | - |
dc.description.abstract | This study aimed to assess how to enhance the value of 18F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, 18F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. 14C-2-Deoxy-D-glucose (14C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuron ratio of 14C-DG uptake increased with up to 10 mM of glucose. Finally, 10 low-grade and 17 high-grade glioma patients underwent fasting and glucose loading 18F-FDG PET/CT and the TNR was compared between scans. The effect of glucose loading was significant in high-grade but not in low-grade gliomas. The receiver operating characteristic curve analyses with a cut-off TNR of 0.81 showed a higher area under the curve after glucose loading than fasting for differentiating low-grade versus high-grade gliomas. In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in 18F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of 18F-FDG PET/CT for grading. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Glucose Loading Enhances the Value of 18 F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Dongwoo Kim | - |
dc.contributor.googleauthor | Hae Young Ko | - |
dc.contributor.googleauthor | Sangwon Lee | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Sujin Ryu | - |
dc.contributor.googleauthor | Seon Yoo Kim | - |
dc.contributor.googleauthor | Jee-In Chung | - |
dc.contributor.googleauthor | Misu Lee | - |
dc.contributor.googleauthor | Ju Hyung Moon | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.identifier.doi | 10.3390/cancers12071977 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A01383 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A05374 | - |
dc.contributor.localId | A05304 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 32698507 | - |
dc.subject.keyword | 18F-FDG PET/CT | - |
dc.subject.keyword | glioma | - |
dc.subject.keyword | glucose loading | - |
dc.subject.keyword | grading | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 문주형 | - |
dc.contributor.affiliatedAuthor | 장종희 | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.contributor.affiliatedAuthor | 이미수 | - |
dc.contributor.affiliatedAuthor | 김동우 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1977 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.12(7) : 1977, 2020-07 | - |
dc.identifier.rimsid | 67147 | - |
dc.type.rims | ART | - |
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