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Glucose Loading Enhances the Value of 18 F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas

DC Field Value Language
dc.contributor.author이용호-
dc.contributor.author문주형-
dc.contributor.author장종희-
dc.contributor.author윤미진-
dc.contributor.author이미수-
dc.contributor.author김동우-
dc.date.accessioned2020-09-29T04:52:41Z-
dc.date.available2020-09-29T04:52:41Z-
dc.date.issued2020-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179525-
dc.description.abstractThis study aimed to assess how to enhance the value of 18F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, 18F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. 14C-2-Deoxy-D-glucose (14C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuron ratio of 14C-DG uptake increased with up to 10 mM of glucose. Finally, 10 low-grade and 17 high-grade glioma patients underwent fasting and glucose loading 18F-FDG PET/CT and the TNR was compared between scans. The effect of glucose loading was significant in high-grade but not in low-grade gliomas. The receiver operating characteristic curve analyses with a cut-off TNR of 0.81 showed a higher area under the curve after glucose loading than fasting for differentiating low-grade versus high-grade gliomas. In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in 18F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of 18F-FDG PET/CT for grading.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGlucose Loading Enhances the Value of 18 F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDongwoo Kim-
dc.contributor.googleauthorHae Young Ko-
dc.contributor.googleauthorSangwon Lee-
dc.contributor.googleauthorYong-Ho Lee-
dc.contributor.googleauthorSujin Ryu-
dc.contributor.googleauthorSeon Yoo Kim-
dc.contributor.googleauthorJee-In Chung-
dc.contributor.googleauthorMisu Lee-
dc.contributor.googleauthorJu Hyung Moon-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.3390/cancers12071977-
dc.contributor.localIdA02989-
dc.contributor.localIdA01383-
dc.contributor.localIdA03470-
dc.contributor.localIdA02550-
dc.contributor.localIdA05374-
dc.contributor.localIdA05304-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid32698507-
dc.subject.keyword18F-FDG PET/CT-
dc.subject.keywordglioma-
dc.subject.keywordglucose loading-
dc.subject.keywordgrading-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor문주형-
dc.contributor.affiliatedAuthor장종희-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이미수-
dc.contributor.affiliatedAuthor김동우-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPage1977-
dc.identifier.bibliographicCitationCANCERS, Vol.12(7) : 1977, 2020-07-
dc.identifier.rimsid67147-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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