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Radiotherapy-Induced High Neutrophil-to-Lymphocyte Ratio is a Negative Prognostic Factor in Patients with Breast Cancer

DC FieldValueLanguage
dc.contributor.author박소은-
dc.contributor.author박세호-
dc.contributor.author김승일-
dc.contributor.author정준-
dc.contributor.author차치환-
dc.contributor.author배숭준-
dc.contributor.author안성귀-
dc.contributor.author김두레-
dc.contributor.author이혜선-
dc.contributor.author박주영-
dc.date.accessioned2020-09-29T04:52:18Z-
dc.date.available2020-09-29T04:52:18Z-
dc.date.issued2020-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179524-
dc.description.abstractRadiotherapy (RT) is the standard of care following breast-conserving operation in breast cancer patients. The neutrophil-to-lymphocyte ratio (NLR) reflects the systemic change caused as a result of the radiotherapy. We aimed to evaluate the association between RT and the change in NLR following the receipt of RT, and to investigate the prognostic impact. We retrospectively reviewed NLR values of breast cancer patients taken before the administration of the first and the last session of RT. The cut-off point for the NLR was determined using the Youden index and receiver operating characteristic (ROC) curve within the training set. Recurrence-free survival (RFS), distant metastasis free survival, and overall survival were the main outcomes. Patients with an NLR higher than 3.49 after RT were classified to an RT-induced high NLR group and showed a significantly higher recurrence rate compared to those with low NLR (p < 0.001). In a multivariate Cox proportional hazards model, RT-induced high NLR remained a significant prognostic factor (HR 2.194, 95% CI 1.230-3.912, p = 0.008 for tumor recurrence. We demonstrated that an increase in NLR over the course of RT has a negative impact on survival, putting these patients with RT-susceptible host immunity at a higher risk of tumor recurrence.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRadiotherapy-Induced High Neutrophil-to-Lymphocyte Ratio is a Negative Prognostic Factor in Patients with Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorChang Ik Yoon-
dc.contributor.googleauthorDooreh Kim-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorSoong June Bae-
dc.contributor.googleauthorChihwan Cha-
dc.contributor.googleauthorSoeun Park-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJu Young Park-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.3390/cancers12071896-
dc.contributor.localIdA05726-
dc.contributor.localIdA01524-
dc.contributor.localIdA01524-
dc.contributor.localIdA00658-
dc.contributor.localIdA00658-
dc.contributor.localIdA03727-
dc.contributor.localIdA03727-
dc.contributor.localIdA05731-
dc.contributor.localIdA05731-
dc.contributor.localIdA05345-
dc.contributor.localIdA05345-
dc.contributor.localIdA02231-
dc.contributor.localIdA02231-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid32674376-
dc.subject.keywordbreast cancer-
dc.subject.keywordneutrophil-to-lymphocyte ratio-
dc.subject.keywordradiation therapy-
dc.contributor.alternativeNamePark, So Eun-
dc.contributor.affiliatedAuthor박소은-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor김승일-
dc.contributor.affiliatedAuthor김승일-
dc.contributor.affiliatedAuthor정준-
dc.contributor.affiliatedAuthor정준-
dc.contributor.affiliatedAuthor차치환-
dc.contributor.affiliatedAuthor차치환-
dc.contributor.affiliatedAuthor배숭준-
dc.contributor.affiliatedAuthor배숭준-
dc.contributor.affiliatedAuthor안성귀-
dc.contributor.affiliatedAuthor안성귀-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPage1896-
dc.identifier.bibliographicCitationCANCERS, Vol.12(7) : 1896, 2020-07-
dc.identifier.rimsid67126-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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