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Muscle Characteristics Obtained Using Computed Tomography as Prognosticators in Patients with Castration-Resistant Prostate Cancer

DC FieldValueLanguage
dc.contributor.author나군호-
dc.contributor.author박지수-
dc.contributor.author이종수-
dc.contributor.author장원식-
dc.contributor.author허지은-
dc.contributor.author함원식-
dc.contributor.author최영득-
dc.date.accessioned2020-09-29T04:51:49Z-
dc.date.available2020-09-29T04:51:49Z-
dc.date.issued2020-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179523-
dc.description.abstractLimited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on castration-resistant prostate cancer (CRPC) outcomes. Skeletal muscle index (SMI) and skeletal muscle attenuation (SMA) were measured for 411 patients at the L3 vertebral level using computed tomography at CRPC diagnosis and were dived to low and high groups at the value of median. Analysis of the skeletal phenotypes and age (<70 and >70 years) was performed to evaluate the effect of SMI and SMA. The median survival rates for patients with low and high SMI were 19 and 24 months (p = 0.015), and those with low and high SMAs were 15 and 26 months (p < 0.001), respectively. In the subgroup analysis by age, SMA was a significant prognosticator in both groups, while SMI was a significant prognosticator only in patients aged >70 years. Patients with low SMA + low SMI had the worst prognosis. Muscle characteristics seems to be a prognosticator in survival of CRPC patients and may be considered in treatment planning.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMuscle Characteristics Obtained Using Computed Tomography as Prognosticators in Patients with Castration-Resistant Prostate Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorJongsoo Lee-
dc.contributor.googleauthorJee Soo Park-
dc.contributor.googleauthorJi Eun Heo-
dc.contributor.googleauthorHyun Kyu Ahn-
dc.contributor.googleauthorWon Sik Jang-
dc.contributor.googleauthorWon Sik Ham-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorYoung Deuk Choi-
dc.identifier.doi10.3390/cancers12071864-
dc.contributor.localIdA01227-
dc.contributor.localIdA05336-
dc.contributor.localIdA05336-
dc.contributor.localIdA05500-
dc.contributor.localIdA05500-
dc.contributor.localIdA05268-
dc.contributor.localIdA05268-
dc.contributor.localIdA05531-
dc.contributor.localIdA05531-
dc.contributor.localIdA04337-
dc.contributor.localIdA04337-
dc.contributor.localIdA04111-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid32664444-
dc.subject.keywordbody composition-
dc.subject.keywordcastration-resistant prostate cancer-
dc.subject.keywordcomputed tomography-
dc.subject.keywordprognosticator-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor이종수-
dc.contributor.affiliatedAuthor이종수-
dc.contributor.affiliatedAuthor장원식-
dc.contributor.affiliatedAuthor장원식-
dc.contributor.affiliatedAuthor허지은-
dc.contributor.affiliatedAuthor허지은-
dc.contributor.affiliatedAuthor함원식-
dc.contributor.affiliatedAuthor함원식-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor최영득-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPage1864-
dc.identifier.bibliographicCitationCANCERS, Vol.12(7) : 1864, 2020-07-
dc.identifier.rimsid67134-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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