Cited 8 times in
Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김상우 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 김혜련 | - |
dc.date.accessioned | 2020-09-29T04:51:38Z | - |
dc.date.available | 2020-09-29T04:51:38Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179522 | - |
dc.description.abstract | Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250). CD200R1 was identified as an independent prognostic factor and validated in GEO and TCGA database. CD2000R1 mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover, CD200R1 was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated with CD200R1 expression. Samples with higher CD200R1 expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) | - |
dc.contributor.googleauthor | Hyun Chang | - |
dc.contributor.googleauthor | Yun-Gyoo Lee | - |
dc.contributor.googleauthor | Yoon Ho Ko | - |
dc.contributor.googleauthor | Jang Ho Cho | - |
dc.contributor.googleauthor | Jong-Kwon Choi | - |
dc.contributor.googleauthor | Keon Uk Park | - |
dc.contributor.googleauthor | Eun Joo Kang | - |
dc.contributor.googleauthor | Keun-Wook Lee | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Jin-Soo Kim | - |
dc.contributor.googleauthor | Hyun Woo Lee | - |
dc.contributor.googleauthor | Min Kyoung Kim | - |
dc.contributor.googleauthor | In Gyu Hwang | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.contributor.googleauthor | Byung-Ho Nam | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.identifier.doi | 10.3390/cancers12071777 | - |
dc.contributor.localId | A00524 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A01166 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 32635224 | - |
dc.subject.keyword | CD2000R1 | - |
dc.subject.keyword | head and neck cancer | - |
dc.subject.keyword | immune cell | - |
dc.subject.keyword | mRNA expression | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kim, Sang Woo | - |
dc.contributor.affiliatedAuthor | 김상우 | - |
dc.contributor.affiliatedAuthor | 임선민 | - |
dc.contributor.affiliatedAuthor | 김혜련 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1777 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.12(7) : 1777, 2020-07 | - |
dc.identifier.rimsid | 67142 | - |
dc.type.rims | ART | - |
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