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Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma

Authors
 Hyun Chang  ;  Yun-Gyoo Lee  ;  Yoon Ho Ko  ;  Jang Ho Cho  ;  Jong-Kwon Choi  ;  Keon Uk Park  ;  Eun Joo Kang  ;  Keun-Wook Lee  ;  Sun Min Lim  ;  Jin-Soo Kim  ;  Hyun Woo Lee  ;  Min Kyoung Kim  ;  In Gyu Hwang  ;  Sangwoo Kim  ;  Byung-Ho Nam  ;  Hye Ryun Kim 
Citation
 CANCERS, Vol.12(7) : 1777, 2020-07 
Journal Title
CANCERS
Issue Date
2020-07
Keywords
CD2000R1 ; head and neck cancer ; immune cell ; mRNA expression ; prognosis
Abstract
Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250). CD200R1 was identified as an independent prognostic factor and validated in GEO and TCGA database. CD2000R1 mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover, CD200R1 was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated with CD200R1 expression. Samples with higher CD200R1 expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy.
Files in This Item:
T202002863.pdf Download
DOI
10.3390/cancers12071777
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sangwoo(김상우) ORCID logo https://orcid.org/0000-0001-5356-0827
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Lim, Sun Min(임선민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179522
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