Cited 2 times in
Determinants and Clinical Outcomes of Extended Dual Antiplatelet Therapy over 3 Years after Drug-Eluting Stent Implantation: A Retrospective Analysis
DC Field | Value | Language |
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dc.contributor.author | 신동호 | - |
dc.contributor.author | 이오현 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 홍성진 | - |
dc.contributor.author | 홍명기 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 안철민 | - |
dc.date.accessioned | 2020-09-29T04:49:55Z | - |
dc.date.available | 2020-09-29T04:49:55Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179513 | - |
dc.description.abstract | Purpose: Although current guidelines recommend the administration of dual antiplatelet therapy (DAPT) for up to 12 months after the implantation of a drug-eluting stent (DES), extended DAPT is frequently used in real-world practice. Materials and methods: From the Korean Multicenter Angioplasty Team registry, we identified a total of 1414 patients who used DAPT for >3 years after DES implantation (extended-DAPT group) and conducted a landmark analysis at 36 months after the index procedure. We evaluated the determinants for and long-term outcomes of extended DAPT and compared the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE), defined as the composite of all-cause death, myocardial infarction, stent thrombosis, and stroke, between the extended-DAPT group and the guideline-DAPT group [DAPT <1 year after DES implantation (n=1273)]. Results: Multivariate analysis indicated the occurrence of acute coronary syndrome as the most significant clinical determinant of the use of extended DAPT. Bifurcation, stent diameter ≤3.0 mm, total stented length ≥28 mm, and use of first-generation DESs were also significant angiographic and procedural determinants. MACCE rates were similar between the extended-DAPT group and the guideline-DAPT group in crude analysis [hazard ratio (HR), 1.08; 95% confidence interval (CI), 0.69-1.68; p=0.739] and after propensity matching (HR, 1.22; 95% CI, 0.72-2.07; p=0.453). Major bleeding rates were comparable between the two groups. Conclusion: In patients undergoing percutaneous coronary intervention, indefinite use of DAPT does not show superior outcomes to those of guideline-DAPT. Major bleeding rates are also similar. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Coronary Syndrome / drug therapy* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiovascular Diseases / epidemiology | - |
dc.subject.MESH | Coronary Artery Disease / drug therapy* | - |
dc.subject.MESH | Coronary Artery Disease / surgery | - |
dc.subject.MESH | Coronary Artery Disease / therapy | - |
dc.subject.MESH | Coronary Thrombosis / prevention & control | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drug-Eluting Stents / adverse effects* | - |
dc.subject.MESH | Dual Anti-Platelet Therapy / methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemorrhage / chemically induced | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction / drug therapy | - |
dc.subject.MESH | Myocardial Infarction / etiology | - |
dc.subject.MESH | Myocardial Infarction / therapy* | - |
dc.subject.MESH | Percutaneous Coronary Intervention / adverse effects* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / administration & dosage* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / adverse effects | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / therapeutic use* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stroke / etiology | - |
dc.subject.MESH | Thrombosis / complications | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Determinants and Clinical Outcomes of Extended Dual Antiplatelet Therapy over 3 Years after Drug-Eluting Stent Implantation: A Retrospective Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Oh Hyun Lee | - |
dc.contributor.googleauthor | Byeong Keuk Kim | - |
dc.contributor.googleauthor | Sung Jin Hong | - |
dc.contributor.googleauthor | Seunghwan Kim | - |
dc.contributor.googleauthor | Chul Min Ahn | - |
dc.contributor.googleauthor | Dong Ho Shin | - |
dc.contributor.googleauthor | Jung Sun Kim | - |
dc.contributor.googleauthor | Tae Soo Kang | - |
dc.contributor.googleauthor | Young Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Myeong Ki Hong | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.3349/ymj.2020.61.7.597 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A05164 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04403 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A02269 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 32608203 | - |
dc.subject.keyword | Antiplatelet therapy | - |
dc.subject.keyword | drug-eluting stent | - |
dc.subject.keyword | percutaneous coronary intervention | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | 신동호 | - |
dc.contributor.affiliatedAuthor | 이오현 | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.contributor.affiliatedAuthor | 김중선 | - |
dc.contributor.affiliatedAuthor | 김병극 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.contributor.affiliatedAuthor | 홍성진 | - |
dc.contributor.affiliatedAuthor | 홍명기 | - |
dc.contributor.affiliatedAuthor | 최동훈 | - |
dc.contributor.affiliatedAuthor | 안철민 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 597 | - |
dc.citation.endPage | 605 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.61(7) : 597-605, 2020-07 | - |
dc.identifier.rimsid | 67106 | - |
dc.type.rims | ART | - |
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