0 51

Cited 0 times in

Multicenter Study on the Diagnostic Performance of Native-T1 Cardiac Magnetic Resonance of Chronic Myocardial Infarctions at 3T

DC FieldValueLanguage
dc.contributor.author장혁재-
dc.contributor.author이상은-
dc.date.accessioned2020-09-29T01:15:12Z-
dc.date.available2020-09-29T01:15:12Z-
dc.date.issued2020-06-
dc.identifier.issn1941-9651-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179453-
dc.description.abstractBackground: Preclinical studies and pilot patient studies have shown that chronic infarctions can be detected and characterized from cardiac magnetic resonance without gadolinium-based contrast agents using native-T1 maps at 3T. We aimed to investigate the diagnostic capacity of this approach for characterizing chronic myocardial infarctions (MIs) in a multi-center setting. Methods: Patients with a prior MI (n=105) were recruited at 3 different medical centers and were imaged with native-T1 mapping and late gadolinium enhancement (LGE) at 3T. Infarct location, size, and transmurality were determined from native-T1 maps and LGE. Sensitivity, specificity, receiver-operating characteristic metrics, and inter- and intraobserver variabilities were assessed relative to LGE. Results: Across all subjects, T1 of MI territory was 1621±110 ms, and remote territory was 1225±75 ms. Sensitivity, specificity, and area under curve for detecting MI location based on native-T1 mapping relative to LGE were 88%, 92%, and 0.93, respectively. Native-T1 maps were not different for measuring infarct size (native-T1 maps: 12.1±7.5%; LGE: 11.8±7.2%, P=0.82) and were in agreement with LGE (R2=0.92, bias, 0.09±2.6%). Corresponding inter- and intraobserver assessments were also highly correlated (interobserver: R2=0.90, bias, 0.18±2.4%; and intraobserver: R2=0.91, bias, 0.28±2.1%). Native T1 maps were not different for measuring MI transmurality (native-T1 maps: 49.1±15.8%; LGE: 47.2±19.0%, P=0.56) and showed agreement (R2=0.71; bias, 1.32±10.2%). Corresponding inter- and intraobserver assessments were also in agreement (interobserver: R2=0.81, bias, 0.1±9.4%; and intraobserver: R2=0.91, bias, 0.28±2.1%, respectively). While the overall accuracy for detecting MI with native-T1 maps at 3T was high, logistic regression analysis showed that MI location was a prominent confounder. Conclusions: Native-T1 mapping can be used to image chronic MI with high degree of accuracy, and as such, it is a viable alternative for scar imaging in patients with chronic MI who are contraindicated for LGE. Technical advancements may be needed to overcome the imaging confounders that currently limit native-T1 mapping from reaching equivalent detection levels as LGE.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfCIRCULATION-CARDIOVASCULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMulticenter Study on the Diagnostic Performance of Native-T1 Cardiac Magnetic Resonance of Chronic Myocardial Infarctions at 3T-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorGuan Wang-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorQi Yang-
dc.contributor.googleauthorVignesh Sadras-
dc.contributor.googleauthorSuraj Patel-
dc.contributor.googleauthorHsin-Jung Yang-
dc.contributor.googleauthorBehzad Sharif-
dc.contributor.googleauthorAvinash Kali-
dc.contributor.googleauthorIvan Cokic-
dc.contributor.googleauthorGuoxi Xie-
dc.contributor.googleauthorMourad Tighiouart-
dc.contributor.googleauthorJeremy Collins-
dc.contributor.googleauthorDebiao Li-
dc.contributor.googleauthorDaniel S Berman-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorRohan Dharmakumar-
dc.identifier.doi10.1161/CIRCIMAGING.119.009894-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ00538-
dc.identifier.eissn1942-0080-
dc.identifier.pmid32507020-
dc.identifier.urlhttps://www.ahajournals.org/doi/full/10.1161/CIRCIMAGING.119.009894-
dc.subject.keywordarea under curve-
dc.subject.keywordcontrast media-
dc.subject.keywordgadolinium-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordmyocardial infarction-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume13-
dc.citation.number6-
dc.citation.startPagee009894-
dc.identifier.bibliographicCitationCIRCULATION-CARDIOVASCULAR IMAGING, Vol.13(6) : e009894, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.