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Cognitive anosognosia is associated with frontal dysfunction and lower depression in Parkinson's disease

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dc.contributor.author유한수-
dc.contributor.author예병석-
dc.contributor.author손영호-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2020-09-29T01:13:32Z-
dc.date.available2020-09-29T01:13:32Z-
dc.date.issued2020-06-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179446-
dc.description.abstractBackground and purpose: Anosognosia refers to a deficit of self-awareness or impaired insight for cognitive and behavioral problems. Cognitive anosognosia was explored in de novo patients with Parkinson's disease (PD) and its relationship to cognitive function and neuropsychiatric symptoms was investigated. Methods: The cross-sectional study enrolled 340 drug-naïve patients with PD. According to the presence of mild cognitive impairment (MCI) and subjective cognitive complaint, patients were classified as patients with cognitive anosognosia (PD-CA, n = 74), with normal cognitive recognition (PD-NR, n = 184) or with cognitive underestimation (PD-CU, n = 82). After controlling for covariates, cognitive performance and neuropsychiatric symptoms were compared between the PD groups. Results: Cognitive anosognosia was found in 21.8% of patients with de novo PD. The PD-CA group showed poorer performance in all cognitive domains except for attention. Amongst PD patients with MCI, those with cognitive anosognosia showed lower composite z-scores in the Stroop color reading test than those without. The Beck Depression Inventory score in the PD-NR group was lower than that in the PD-CU group and higher than that in the PD-CA group. The Cognitive Complaints Interview score mediated the association between cognitive anosognosia and Beck Depression Inventory score. Conclusions: Cognitive anosognosia in PD was associated with greater frontal dysfunction and lower depression. Since cognitive anosognosia has a harmful impact on PD patients and their caregivers due to overestimation of their abilities in everyday life, early identification of cognitive anosognosia in PD is important in management and prognosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCognitive anosognosia is associated with frontal dysfunction and lower depression in Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorH S Yoo-
dc.contributor.googleauthorS J Chung-
dc.contributor.googleauthorY H Lee-
dc.contributor.googleauthorB S Ye-
dc.contributor.googleauthorY H Sohn-
dc.contributor.googleauthorP H Lee-
dc.identifier.doi10.1111/ene.14188-
dc.contributor.localIdA05367-
dc.contributor.localIdA04603-
dc.contributor.localIdA01982-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid32090410-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/ene.14188-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordcognitive anosognosia-
dc.subject.keyworddepression-
dc.subject.keywordsubjective cognitive complaint-
dc.contributor.alternativeNameYoo, Han Soo-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume27-
dc.citation.number6-
dc.citation.startPage951-
dc.citation.endPage958-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.27(6) : 951-958, 2020-06-
dc.identifier.rimsid67550-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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