Cited 6 times in
Gender-specific effect of urate on white matter integrity in Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 유한수 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이양현 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.date.accessioned | 2020-09-29T01:11:05Z | - |
dc.date.available | 2020-09-29T01:11:05Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179427 | - |
dc.description.abstract | Objectives: To investigate the potential protective influence of serum uric acid (UA) level on white matter (WM) microstructural changes in de novo Parkinson's disease (PD). Methods: We enrolled a total of 184 patients with drug-naïve de novo PD and 59 age and gender-matched controls that underwent diffusion tensor imaging (DTI). Based on the distribution, serum UA levels were stratified into tertiles in PD patients by gender. Using tract-based spatial statistics (TBSS) analysis, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were used to compare WM integrity between the groups. Results: Interaction analysis showed that interaction effect on FA values between gender and UA levels in PD was significant in widespread WM areas, including frontal-parieto-temporal, corpus callosum, bilateral internal and external capsule, and thalamic regions. Multiple regression analysis revealed that FA values had a significantly positive correlation with UA levels across widespread WM areas in male patients. However, there was no significant correlation between DTI measures and UA levels in female patients. In a group comparison in male patients, PD with the lowest UA level (PD-L-UA) group showed significantly lower FA and higher MD and RD values in frontal-parieto-temporal WM regions than PD with the highest UA level (PD-H-UA) group. However, female patients did not show significant difference of DTI measures between PD-L-UA and PD-H-UA groups. Conclusions: The present study demonstrated that the serum UA levels may have the potentially gender-specific close relationship with WM integrity in the early stage of PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | PARKINSONISM & RELATED DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Gender-specific effect of urate on white matter integrity in Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Yang Hyun Lee | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Yoonju Lee | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Jungho Cha | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1016/j.parkreldis.2020.05.012 | - |
dc.contributor.localId | A05367 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A05714 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J02468 | - |
dc.identifier.eissn | 1873-5126 | - |
dc.identifier.pmid | 32474403 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1353802020301218 | - |
dc.subject.keyword | Diffusion tensor imaging | - |
dc.subject.keyword | Gender-specific | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | Uric acid | - |
dc.subject.keyword | White matter integrity | - |
dc.contributor.alternativeName | Yoo, Han Soo | - |
dc.contributor.affiliatedAuthor | 유한수 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이양현 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 75 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 47 | - |
dc.identifier.bibliographicCitation | PARKINSONISM & RELATED DISORDERS, Vol.75 : 41-47, 2020-06 | - |
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