15 24

Cited 0 times in

High Preoperative Serum Syndecan-1, a Marker of Endothelial Glycocalyx Degradation, and Severe Acute Kidney Injury after Valvular Heart Surgery

DC FieldValueLanguage
dc.contributor.author송종욱-
dc.contributor.author소사라-
dc.contributor.author곽영란-
dc.contributor.author김혜빈-
dc.date.accessioned2020-09-29T00:41:23Z-
dc.date.available2020-09-29T00:41:23Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179367-
dc.description.abstractDegradation of endothelial glycocalyx (EG) is associated with inflammation and endothelial dysfunction, which may contribute to the development of acute kidney injury (AKI). We investigated the association between a marker of EG degradation and AKI after valvular heart surgery. Serum syndecan-1 concentrations were measured at induction of anesthesia and discontinuation of cardiopulmonary bypass in 250 patients. Severe AKI was defined as Kidney Disease: Improving Global Outcomes Criteria Stage 2 or 3. Severe AKI occurred in 13 patients (5%). Receiver operating characteristic analysis of preoperative syndecan-1 to predict severe AKI showed area under curve of 0.714 (95% confidence interval (CI), 0.575-0.853; p = 0.009). The optimal cut-off value was 90 ng/mL, with a sensitivity of 61.5% and specificity of 78.5%. In multivariable analysis, both preoperative syndecan-1 ≥ 90 ng/mL and Cleveland Clinic Foundation score independently predicted severe AKI. Severe tricuspid regurgitation was more frequent (42.4% vs. 17.8%, p < 0.001), and baseline right ventricular systolic pressure (41 (33-51) mmHg vs. 33 (27-43) mmHg, p = 0.001) and TNF-α (1.85 (1.37-2.43) pg/mL vs. 1.45 (1.14-1.92) pg/mL, p <0.001) were higher in patients with high preoperative syndecan-1. Patients with high preoperative syndecan-1 had longer hospital stay (16 (12-24) days vs. 13 (11-17) days, p = 0.001). In conclusion, a high preoperative syndecan-1 concentration greater than 90 ng/mL was able to predict severe AKI after valvular heart surgery and was associated with prolonged hospitalization.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHigh Preoperative Serum Syndecan-1, a Marker of Endothelial Glycocalyx Degradation, and Severe Acute Kidney Injury after Valvular Heart Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorHye-Bin Kim-
dc.contributor.googleauthorSarah Soh-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.contributor.googleauthorJae Chan Bae-
dc.contributor.googleauthorSang Hwa Kang-
dc.contributor.googleauthorJong Wook Song-
dc.identifier.doi10.3390/jcm9061803-
dc.contributor.localIdA02060-
dc.contributor.localIdA01960-
dc.contributor.localIdA01960-
dc.contributor.localIdA00172-
dc.contributor.localIdA00172-
dc.contributor.localIdA05850-
dc.contributor.localIdA05850-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid32531891-
dc.subject.keywordacute kidney injury-
dc.subject.keywordcardiac surgical procedures-
dc.subject.keywordendothelium-
dc.subject.keywordglycocalyx-
dc.subject.keywordsyndecan-1-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.affiliatedAuthor송종욱-
dc.contributor.affiliatedAuthor소사라-
dc.contributor.affiliatedAuthor소사라-
dc.contributor.affiliatedAuthor곽영란-
dc.contributor.affiliatedAuthor곽영란-
dc.contributor.affiliatedAuthor김혜빈-
dc.contributor.affiliatedAuthor김혜빈-
dc.citation.volume9-
dc.citation.number6-
dc.citation.startPage1803-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.9(6) : 1803, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.