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Prevalence, predictors, and prognosis of tricuspid regurgitation following permanent pacemaker implantation

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dc.contributor.author심지영-
dc.contributor.author서지원-
dc.contributor.author홍그루-
dc.contributor.author하종원-
dc.contributor.author조익성-
dc.date.accessioned2020-09-28T12:04:55Z-
dc.date.available2020-09-28T12:04:55Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179330-
dc.description.abstractThis study aimed to investigate the prevalence and clinical significance of lead-related tricuspid regurgitation (TR) in patients with permanent pacemaker (PM). A total of 2,533 patients who underwent permanent PM implantation between January 2008 and December 2017 in a single center were retrospectively reviewed. Among them, 429 patients who underwent transthoracic echocardiography within 90 days before implantation and were followed up at least 3 months after PM implantation were included. Patients who had pre-existing grade 3 or 4 TR, had a single atrial lead, or had undergone tricuspid valve surgery before PM implantation were excluded. Occurrence of PM-related TR (PMTR) was defined as worsening of TR by at least 2 grades on follow-up echocardiography. Cardiovascular outcomes were defined as the composite of cardiovascular death and hospitalization for heart failure. During the median follow-up of 855 days, 42 (9.8%) patients had PMTR and 86 (20.0%) presented with cardiovascular outcomes. In the multivariate logistic regression analysis, the presence of atrial fibrillation (hazard ratio [HR]: 2.07, 95% confidence interval [CI]: 1.27-4.09, p = 0.037]) and history of open-heart surgery (HR: 3.34, 95% CI: 1.68-6.68, p<0.001) were independently associated with PMTR. Patients with PMTR showed significantly higher cardiovascular events than those without (45.2 vs. 17.3%, log-rank p<0.001). Furthermore, PMTR was independently associated with the primary outcome (HR: 2.45, 95% CI: 1.43-4.22, p = 0.001). In conclusion, the occurrence of TR in patients with permanent PM is not uncommon. PMTR is associated with atrial fibrillation, the history of open-heart surgery, and poorer cardiovascular outcomes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPacemaker, Artificial / adverse effects*-
dc.subject.MESHPrevalence-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTricuspid Valve Insufficiency / diagnosis*-
dc.subject.MESHTricuspid Valve Insufficiency / epidemiology*-
dc.subject.MESHTricuspid Valve Insufficiency / etiology-
dc.titlePrevalence, predictors, and prognosis of tricuspid regurgitation following permanent pacemaker implantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJiwon Seo-
dc.contributor.googleauthorDae-Young Kim-
dc.contributor.googleauthorIksung Cho-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorChi Young Shim-
dc.identifier.doi10.1371/journal.pone.0235230-
dc.contributor.localIdA02213-
dc.contributor.localIdA01913-
dc.contributor.localIdA04386-
dc.contributor.localIdA04257-
dc.contributor.localIdA03888-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid32589674-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.affiliatedAuthor심지영-
dc.contributor.affiliatedAuthor서지원-
dc.contributor.affiliatedAuthor홍그루-
dc.contributor.affiliatedAuthor하종원-
dc.contributor.affiliatedAuthor조익성-
dc.citation.volume15-
dc.citation.number6-
dc.citation.startPagee0235230-
dc.identifier.bibliographicCitationPLOS ONE, Vol.15(6) : e0235230, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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