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Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

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dc.contributor.author박용범-
dc.date.accessioned2020-09-28T12:03:13Z-
dc.date.available2020-09-28T12:03:13Z-
dc.date.issued2020-06-
dc.identifier.issn1478-6354-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179325-
dc.description.abstractBackgrounds: Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs. The aim of this study is to design photothermally controlled drug release from multifunctional nanoparticles (MNPs) at a near-infrared (NIR) irradiated site to improve therapeutic efficacy for RA and reduce side effects. Methods: Au film was deposited onto methotrexate (MTX)-loaded poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PLGA) nanoparticles, resulting in MTX-loaded MNPs. The synergistic effects of MTX-loaded MNPs with NIR irradiation were investigated using RA fibroblast-like synoviocytes (FLSs) and collagen-induced arthritis (CIA) mice. Results: Upon NIR irradiation, NIR resonance of the Au half-shell generated heat locally, accelerating MTX release from PLGA nanoparticles. In vivo NIR images of MTX-loaded MNPs indicated effective delivery of the MNPs to the inflamed joints. Moreover, in collagen-induced arthritis mice, MTX-loaded MNPs containing 1/1400 of MTX solution (repeated-dose administration) had therapeutic effects comparable to conventional treatment with MTX solution. In vitro experiments showed higher therapeutic efficacy of MTX-loaded MNPs with NIR irradiation than that of chemotherapy alone. Conclusions: A combination therapy of MTX-loaded MNP and NIR irradiation showed durable and good treatment efficacy for the suppression of arthritis in a single administration of small dose of MTX. Our results demonstrate that the treatment modality using drug-loaded MNP with NIR irradiation may be a promising therapeutic strategy for the treatment of RA and allow in vivo NIR optical imaging.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfARTHRITIS RESEARCH & THERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMethotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYou-Jung Ha-
dc.contributor.googleauthorSun-Mi Lee-
dc.contributor.googleauthorChin Hee Mun-
dc.contributor.googleauthorHyung Joon Kim-
dc.contributor.googleauthorYonghee Bae-
dc.contributor.googleauthorJi-Hee Lim-
dc.contributor.googleauthorKyu-Hyung Park-
dc.contributor.googleauthorSoo-Kon Lee-
dc.contributor.googleauthorKyung-Hwa Yoo-
dc.contributor.googleauthorYong-Beom Park-
dc.identifier.doi10.1186/s13075-020-02230-y-
dc.contributor.localIdA01579-
dc.relation.journalcodeJ00241-
dc.identifier.eissn1478-6362-
dc.identifier.pmid32552859-
dc.subject.keywordMethotrexate-
dc.subject.keywordMultifunctional nanoparticle-
dc.subject.keywordPhotothermally controlled drug delivery-
dc.subject.keywordRheumatoid arthritis-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage146-
dc.identifier.bibliographicCitationARTHRITIS RESEARCH & THERAPY, Vol.22(1) : 146, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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