Cited 21 times in
Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study
DC Field | Value | Language |
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dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 조용인 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2020-09-28T12:01:55Z | - |
dc.date.available | 2020-09-28T12:01:55Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179321 | - |
dc.description.abstract | Background: There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is associated with the progression of carotid atherosclerosis in patients with type 2 diabetes. Methods: From a longitudinal cohort, we enrolled 1120 patients with type 2 diabetes who underwent repeated carotid artery ultrasonography every 1-2 years. Ultrasonographic findings at baseline and after 6-8 years were compared. Presence of hepatic steatosis was mainly assessed by abdominal ultrasonography; patients with hepatic steatosis were further evaluated for hepatic fibrosis according to fibrosis-4 index. We investigated the association between liver status and atherosclerosis progression. Results: Of 1120 patients, 636 (56.8%) were classified as having hepatic steatosis at baseline. After 6-8 years, 431 (38.5%) showed atherosclerosis progression. Hepatic steatosis was significantly associated with atherosclerosis progression (adjusted odds ratio[AOR]: 1.370, 95% CI 1.025-1.832; p < 0.05). Among patients with hepatic steatosis, only individuals with fibrosis showed significant association with atherosclerosis progression (AOR: 1.615, 95% CI 1.005-2.598; p < 0.05). The association between hepatic fibrosis and atherosclerosis progression was significant in all metabolic subgroups regardless of age, body mass index, presence of metabolic syndrome, or insulin sensitivity (all p < 0.05). Furthermore, subjects with hepatic steatosis & fibrosis and ≥ 4 components of metabolic syndrome criteria showed markedly increased risk of atherosclerosis progression (AOR: 2.430, 95% CI 1.087-5.458; p < 0.05). Conclusions: Hepatic steatosis with fibrosis is independently associated with the progression of carotid atherosclerosis in patients with type 2 diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyeok-Hee Lee | - |
dc.contributor.googleauthor | Yongin Cho | - |
dc.contributor.googleauthor | Young Ju Choi | - |
dc.contributor.googleauthor | Byung Wook Huh | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Seok Won Park | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Kap Bum Huh | - |
dc.identifier.doi | 10.1186/s12933-020-01064-x | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A03866 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.pmid | 32534588 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Hepatic fibrosis | - |
dc.subject.keyword | Metabolic syndrome | - |
dc.subject.keyword | Non-alcoholic fatty liver disease | - |
dc.subject.keyword | Non-alcoholic steatohepatitis | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.contributor.affiliatedAuthor | 이병완 | - |
dc.contributor.affiliatedAuthor | 강은석 | - |
dc.contributor.affiliatedAuthor | 조용인 | - |
dc.contributor.affiliatedAuthor | 차봉수 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 81, 2020-06 | - |
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