Cited 15 times in
Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 홍남기 | - |
dc.contributor.author | 남기현 | - |
dc.contributor.author | 이잔디 | - |
dc.contributor.author | 이초록 | - |
dc.contributor.author | 김진경 | - |
dc.contributor.author | 강상욱 | - |
dc.contributor.author | 정종주 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 최선형 | - |
dc.contributor.author | 최순민 | - |
dc.contributor.author | 최혜련 | - |
dc.date.accessioned | 2020-09-28T11:58:22Z | - |
dc.date.available | 2020-09-28T11:58:22Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179306 | - |
dc.description.abstract | Surgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean ± SD], 43.4 ± 14.1 [range, 23-81] years). Total parathyroidectomy with auto-transplantation to the forearm (TPX) was the most common surgical method (17/33), followed by less-than-subtotal parathyroidectomy (LPX; 12/33) and subtotal parathyroidectomy (SPX; 4/33). There was no postoperative persistent hyperparathyroidism. Recurrence was high in the LPX group without significance (1 in TPX, 2 in SPX, and 3 in LPX, p = 0.076). Permanent and transient hypoparathyroidism were more common in TPX (n = 6/17, 35.3%, p = 0.031; n = 4/17, 23.5%, p = 0.154, respectively). Parathyroid venous sampling (PVS) was introduced in 2013 for preoperative localisation of hyperparathyroidism at our hospital; nine among 19 patients operated on after 2013 underwent pre-parathyroidectomy PVS, with various surgical extents, and no permanent hypoparathyroidism (p = 0.033) or post-LPX recurrence was observed. Although TPX with auto-transplantation is the standard surgery for MEN1-related PHPT, surgical extent individualisation is necessary, given the postoperative hypoparathyroidism rate of TPX and feasibility of PVS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hye Ryeon Choi | - |
dc.contributor.googleauthor | Sun Hyung Choi | - |
dc.contributor.googleauthor | Soon Min Choi | - |
dc.contributor.googleauthor | Jin Kyong Kim | - |
dc.contributor.googleauthor | Cho Rok Lee | - |
dc.contributor.googleauthor | Sang-Wook Kang | - |
dc.contributor.googleauthor | Jandee Lee | - |
dc.contributor.googleauthor | Jong Ju Jeong | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Seunghyun Lee | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1038/s41598-020-67424-5 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A05934 | - |
dc.contributor.localId | A04388 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A03066 | - |
dc.contributor.localId | A03256 | - |
dc.contributor.localId | A05739 | - |
dc.contributor.localId | A00032 | - |
dc.contributor.localId | A03722 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A05053 | - |
dc.contributor.localId | A05941 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 32606444 | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.contributor.affiliatedAuthor | 남기현 | - |
dc.contributor.affiliatedAuthor | 이잔디 | - |
dc.contributor.affiliatedAuthor | 이초록 | - |
dc.contributor.affiliatedAuthor | 김진경 | - |
dc.contributor.affiliatedAuthor | 강상욱 | - |
dc.contributor.affiliatedAuthor | 정종주 | - |
dc.contributor.affiliatedAuthor | 정웅윤 | - |
dc.contributor.affiliatedAuthor | 최선형 | - |
dc.contributor.affiliatedAuthor | 최순민 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 10634 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.10(1) : 10634, 2020-06 | - |
dc.identifier.rimsid | 67203 | - |
dc.type.rims | ART | - |
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