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Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism

DC FieldValueLanguage
dc.contributor.author이유미-
dc.contributor.author이승현-
dc.contributor.author홍남기-
dc.contributor.author남기현-
dc.contributor.author이잔디-
dc.contributor.author이초록-
dc.contributor.author김진경-
dc.contributor.author강상욱-
dc.contributor.author정종주-
dc.contributor.author정웅윤-
dc.contributor.author최선형-
dc.contributor.author최순민-
dc.date.accessioned2020-09-28T11:58:22Z-
dc.date.available2020-09-28T11:58:22Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179306-
dc.description.abstractSurgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean ± SD], 43.4 ± 14.1 [range, 23-81] years). Total parathyroidectomy with auto-transplantation to the forearm (TPX) was the most common surgical method (17/33), followed by less-than-subtotal parathyroidectomy (LPX; 12/33) and subtotal parathyroidectomy (SPX; 4/33). There was no postoperative persistent hyperparathyroidism. Recurrence was high in the LPX group without significance (1 in TPX, 2 in SPX, and 3 in LPX, p = 0.076). Permanent and transient hypoparathyroidism were more common in TPX (n = 6/17, 35.3%, p = 0.031; n = 4/17, 23.5%, p = 0.154, respectively). Parathyroid venous sampling (PVS) was introduced in 2013 for preoperative localisation of hyperparathyroidism at our hospital; nine among 19 patients operated on after 2013 underwent pre-parathyroidectomy PVS, with various surgical extents, and no permanent hypoparathyroidism (p = 0.033) or post-LPX recurrence was observed. Although TPX with auto-transplantation is the standard surgery for MEN1-related PHPT, surgical extent individualisation is necessary, given the postoperative hypoparathyroidism rate of TPX and feasibility of PVS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBenefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Ryeon Choi-
dc.contributor.googleauthorSun Hyung Choi-
dc.contributor.googleauthorSoon Min Choi-
dc.contributor.googleauthorJin Kyong Kim-
dc.contributor.googleauthorCho Rok Lee-
dc.contributor.googleauthorSang-Wook Kang-
dc.contributor.googleauthorJandee Lee-
dc.contributor.googleauthorJong Ju Jeong-
dc.contributor.googleauthorKee-Hyun Nam-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorSeunghyun Lee-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorYumie Rhee-
dc.identifier.doi10.1038/s41598-020-67424-5-
dc.contributor.localIdA03012-
dc.contributor.localIdA05934-
dc.contributor.localIdA05934-
dc.contributor.localIdA04388-
dc.contributor.localIdA04388-
dc.contributor.localIdA01245-
dc.contributor.localIdA01245-
dc.contributor.localIdA03066-
dc.contributor.localIdA03066-
dc.contributor.localIdA03256-
dc.contributor.localIdA03256-
dc.contributor.localIdA05739-
dc.contributor.localIdA05739-
dc.contributor.localIdA00032-
dc.contributor.localIdA00032-
dc.contributor.localIdA03722-
dc.contributor.localIdA03722-
dc.contributor.localIdA03674-
dc.contributor.localIdA03674-
dc.contributor.localIdA05053-
dc.contributor.localIdA05053-
dc.contributor.localIdA05941-
dc.contributor.localIdA05941-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32606444-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.affiliatedAuthor이유미-
dc.contributor.affiliatedAuthor이승현-
dc.contributor.affiliatedAuthor이승현-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor남기현-
dc.contributor.affiliatedAuthor남기현-
dc.contributor.affiliatedAuthor이잔디-
dc.contributor.affiliatedAuthor이잔디-
dc.contributor.affiliatedAuthor이초록-
dc.contributor.affiliatedAuthor이초록-
dc.contributor.affiliatedAuthor김진경-
dc.contributor.affiliatedAuthor김진경-
dc.contributor.affiliatedAuthor강상욱-
dc.contributor.affiliatedAuthor강상욱-
dc.contributor.affiliatedAuthor정종주-
dc.contributor.affiliatedAuthor정종주-
dc.contributor.affiliatedAuthor정웅윤-
dc.contributor.affiliatedAuthor정웅윤-
dc.contributor.affiliatedAuthor최선형-
dc.contributor.affiliatedAuthor최선형-
dc.contributor.affiliatedAuthor최순민-
dc.contributor.affiliatedAuthor최순민-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage10634-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 10634, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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