0 358

Cited 5 times in

Plasma immunoglobulin binding protein 1 as a predictor of development of lupus nephritis

DC Field Value Language
dc.contributor.author박민찬-
dc.contributor.author권오찬-
dc.date.accessioned2020-09-28T11:45:56Z-
dc.date.available2020-09-28T11:45:56Z-
dc.date.issued2020-05-
dc.identifier.issn0961-2033-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179282-
dc.description.abstractObjective: Urine levels of immunoglobulin binding protein 1 (IGBP1) are increased in patients with lupus nephritis (LN) compared with systemic lupus erythematosus (SLE) patients without nephritis. However, the clinical significance of IGBP1 level in plasma is unclear. We aimed to evaluate whether the plasma level of IGBP1 can predict future development of LN in SLE patients without nephritis. Methods: Forty-three SLE patients without nephritis were followed for 5 years. Plasma IGBP1 levels were measured using ELISA, and clinical and laboratory data were obtained at study entry. Development of LN was confirmed by renal biopsy. Cox regression analysis was performed to identify factors associated with development of LN, and receiver operating characteristic curve analysis was used to determine the predictive value of each factor. Results: Of the total 43 patients, eight (18.6%) developed LN during the follow-up period. Compared with patients who did not develop LN, those who developed LN had higher levels of plasma IGBP1 (6.3 ng/ml (range 4.3–9.6 ng/mL) vs. 13.3 ng/ml (range 7.2–31.3 ng/ml); p=0.023). In the Cox regression analysis, higher CRP (hazard ratio (HR)=1.325, 95% confidence interval (CI) 1.073–1.637, p=0.009), anti-dsDNA antibody (Ab; HR=1.066, 95% CI 1.012–1.124, p=0.017) and plasma IGBP1 (HR=1.091, 95% CI 1.034–1.152, p=0.002) were associated with future development of LN. Among these factors, anti-dsDNA Ab (area under the curve (AUC)=0.893) had the highest predictive value followed by plasma IGBP1 (AUC=0.761) and CRP (AUC=0.634). A combination of anti-dsDNA Ab and plasma IGBP1 as a composite predictor was highly specific (97%) for predicting the development of LN. Conclusions: Plasma IGBP1 can be used complementarily with anti-dsDNA Ab for detecting SLE patients at a higher risk of developing LN.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSAGE Publications-
dc.relation.isPartOfLUPUS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePlasma immunoglobulin binding protein 1 as a predictor of development of lupus nephritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorOh Chan Kwon-
dc.contributor.googleauthorEun-Ju Lee-
dc.contributor.googleauthorJi Seon Oh-
dc.contributor.googleauthorSeokchan Hong-
dc.contributor.googleauthorChang-Keun Lee-
dc.contributor.googleauthorBin Yoo-
dc.contributor.googleauthorMin-Chan Park-
dc.contributor.googleauthorYong-Gil Kim-
dc.identifier.doi10.1177/0961203320912336-
dc.contributor.localIdA01470-
dc.contributor.localIdA05818-
dc.relation.journalcodeJ02175-
dc.identifier.eissn1477-0962-
dc.identifier.pmid32183589-
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/0961203320912336-
dc.subject.keywordSystemic lupus erythematosus-
dc.subject.keywordimmunoglobulin binding protein 1-
dc.subject.keywordlupus nephritis-
dc.contributor.alternativeNamePark, Min Chan-
dc.contributor.affiliatedAuthor박민찬-
dc.contributor.affiliatedAuthor권오찬-
dc.citation.volume29-
dc.citation.number6-
dc.citation.startPage547-
dc.citation.endPage553-
dc.identifier.bibliographicCitationLUPUS, Vol.29(6) : 547-553, 2020-05-
dc.identifier.rimsid67556-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.