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Sex-dependent association of urate on the patterns of striatal dopamine depletion in Parkinson's disease

DC Field Value Language
dc.contributor.author유한수-
dc.contributor.author손영호-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.contributor.author백경원-
dc.contributor.author정진호-
dc.date.accessioned2020-09-28T11:45:28Z-
dc.date.available2020-09-28T11:45:28Z-
dc.date.issued2020-05-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179280-
dc.description.abstractBackground and purpose: The aim was to investigate the relationship between the serum urate (UA) levels and patterns of striatal dopamine depletion in patients with de novo Parkinson's disease (PD). Methods: In all, 167 de novo PD patients who underwent 18 F-fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane positron emission tomography scans were enrolled. After quantifying dopamine transporter (DAT) availability in each striatal subregion, sex-dependent patterns of striatal dopamine depletion were analysed by measuring (i) dopamine depletion in the other striatal subregions and posterior putamen (intersubregional ratio, ISR) and (ii) the interhemispheric asymmetry of dopamine depletion in the posterior putamen (asymmetric ratio, AR). Results: The interaction analysis revealed a significant interaction effect of sex and serum UA levels on the ISR but not on the AR. The ISR was negatively correlated with the serum UA levels in all patients with PD (r = -0.156, P = 0.045), and this association was more prominent in male PD patients (r = -0.422, P < 0.001). However, no significant association between the AR and serum UA levels was found in any of the patients. In addition, serum UA levels were significantly associated with DAT availability in the posterior putamen on both the more affected side (r = 0.312, P = 0.005) and the less affected side (r = 0.312, P = 0.005) only in male PD patients. Conclusions: The present study demonstrated the potentially close sex-specific relationship between the serum UA levels and the anterior-posterior gradient of DAT patterns, suggesting a sex-specific protective effect of UA on nigrostriatal dopaminergic neurons in de novo PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSex-dependent association of urate on the patterns of striatal dopamine depletion in Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorK Baik-
dc.contributor.googleauthorS J Chung-
dc.contributor.googleauthorH S Yoo-
dc.contributor.googleauthorY H Lee-
dc.contributor.googleauthorJ H Jung-
dc.contributor.googleauthorY H Sohn-
dc.contributor.googleauthorP H Lee-
dc.identifier.doi10.1111/ene.14152-
dc.contributor.localIdA05367-
dc.contributor.localIdA01982-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.contributor.localIdA05133-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid31994785-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/ene.14152-
dc.subject.keywordParkinson’s disease-
dc.subject.keyworddopamine transporter-
dc.subject.keywordsex-
dc.subject.keywordurate-
dc.contributor.alternativeNameYoo, Han Soo-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor백경원-
dc.citation.volume27-
dc.citation.number5-
dc.citation.startPage773-
dc.citation.endPage778-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.27(5) : 773-778, 2020-05-
dc.identifier.rimsid67434-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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