Cited 4 times in

Serum albumin and C-reactive protein as significant predictors of non-relapse mortality in lower gastrointestinal graft-versus-host disease

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dc.contributor.author민유홍-
dc.contributor.author김수정-
dc.contributor.author김진석-
dc.contributor.author장지은-
dc.contributor.author정해림-
dc.contributor.author정준원-
dc.date.accessioned2020-09-28T11:41:38Z-
dc.date.available2020-09-28T11:41:38Z-
dc.date.issued2020-05-
dc.identifier.issn0939-5555-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179253-
dc.description.abstractAcute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is the major cause of non-relapse mortality (NRM) in allogeneic hematopoietic stem cell transplantation (alloHSCT). This study aimed to identify variables associated with corticosteroid response and NRM in patients who developed lower GI aGVHD. We retrospectively analyzed the clinical data of patients treated at Yonsei University Severance Hospital between 2008 and 2017. Among 244 recipients of alloHSCT, 48 (19.7%) were diagnosed as lower GI aGVHD at a median of 22 days after alloHSCT. In these cases, 20 (41.6%) patients were resistant to corticosteroid therapy. Corticosteroid resistance was associated with advanced stage of lower GI aGVHD (P = 0.019), low serum albumin (P = 0.006), and elevated CRP (P = 0.030) on day 7 after corticosteroid therapy. NRM rate was significantly higher in the corticosteroid-resistant group compared with the sensitive group (HR 5.339, P = 0.003). Multivariate analysis revealed serum albumin (P = 0.046), and CRP levels (P = 0.032) were independent prognostic factors for NRM. When the patients were classified into 3 groups according to Glasgow prognostic score (GPS), the rate of corticosteroid resistance was significantly higher in the high GPS group compared with the intermediate or low GPS group (83.3 vs. 27.2 and 15.3%, respectively, P < 0.001). We demonstrated that low serum albumin and elevated CRP level on day 7 after corticosteroid therapy are objective biomarkers of corticosteroid resistance and a significant predictor for higher NRM. These simple and practical parameters could be valuable information predicting response and prognosis in lower GI aGVHD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfANNALS OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSerum albumin and C-reactive protein as significant predictors of non-relapse mortality in lower gastrointestinal graft-versus-host disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHaerim Chung-
dc.contributor.googleauthorJi Eun Jang-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJune-Won Cheong-
dc.identifier.doi10.1007/s00277-020-04015-4-
dc.contributor.localIdA01407-
dc.contributor.localIdA00633-
dc.contributor.localIdA01017-
dc.contributor.localIdA03477-
dc.contributor.localIdA04674-
dc.contributor.localIdA03729-
dc.relation.journalcodeJ00161-
dc.identifier.eissn1432-0584-
dc.identifier.pmid32253453-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s00277-020-04015-4-
dc.subject.keywordBiomarker-
dc.subject.keywordC-reactive protein-
dc.subject.keywordLower gastrointestinal acute graft-versus-host disease-
dc.subject.keywordSerum albumin-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.affiliatedAuthor민유홍-
dc.contributor.affiliatedAuthor김수정-
dc.contributor.affiliatedAuthor김진석-
dc.contributor.affiliatedAuthor장지은-
dc.contributor.affiliatedAuthor정해림-
dc.contributor.affiliatedAuthor정준원-
dc.citation.volume99-
dc.citation.number5-
dc.citation.startPage1111-
dc.citation.endPage1119-
dc.identifier.bibliographicCitationANNALS OF HEMATOLOGY, Vol.99(5) : 1111-1119, 2020-05-
dc.identifier.rimsid67474-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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