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Risk Factors for Mortality in Patients with Elizabethkingia Infection and the Clinical Impact of the Antimicrobial Susceptibility Patterns of Elizabethkingia Species

DC Field Value Language
dc.contributor.author염준섭-
dc.contributor.author송영구-
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author안진영-
dc.date.accessioned2020-09-28T11:32:40Z-
dc.date.available2020-09-28T11:32:40Z-
dc.date.issued2020-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179224-
dc.description.abstractElizabethkingia species (spp.), which can colonize hospital environments, are emerging nosocomial pathogens presenting high mortality. Due to their intrinsic resistance to a broad range of antibiotics, optimal antibiotic dosage has yet to be determined against infections caused by Elizabethkingia spp. This study aimed to investigate the risk factors for the mortality of infections caused by Elizabethkingia spp. and assess the clinical implications of their antimicrobial susceptibility patterns. Data from 210 patients affected by Elizabethkingia-induced pneumonia and bacteremia between 1 November 2005 and 31 May 2016, were analyzed. Further antimicrobial susceptibility tests for moxifloxacin, rifampin, and vancomycin using Elizabethkingia isolates were performed to compensate for the Elizabethkingia spp. susceptibility panel in patients affected after 2013. The mean age of the patients was 66.5 ± 18 years and the 28-day mortality rate was 25.2% (53/210). In the univariate analysis, history of prior stay in an intensive care unit, central venous catheter use, presented thrombocytopenia, immunocompetent status, a high simplified acute physiology score II (SAPS II score), a high C-reactive protein (CRP)/albumin ratio on the day of isolation and seven days later, and a high minimum inhibitory concentration (MIC) value of rifampin were significantly associated with a higher mortality rate. In the multivariate logistic regression analysis, the MIC values of rifampin (odds ratio (OR): 1.045; 95% confidence interval (CI): 1.006-1.085; p = 0.023), SAPS II score (OR: 1.053; 95% CI: 1.022-1.084; p = 0.001), and initial CRP/albumin ratio (OR: 1.030; 95% CI: 1.009-1.051; p = 0.004) were significantly associated with 28-day mortality. To reduce the mortality associated with Elizabethkingia infections, prediction of the clinical course using initial CRP/albumin ratio and SAPS II and early intervention are essential. Rifampin is a promising candidate as the drug of choice in treating Elizabethkingia infections.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRisk Factors for Mortality in Patients with Elizabethkingia Infection and the Clinical Impact of the Antimicrobial Susceptibility Patterns of Elizabethkingia Species-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Seong-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorJun Hyoung Kim-
dc.contributor.googleauthorWoon Ji Lee-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJoon Sup Yeom-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorSu Jin Jeong-
dc.identifier.doi10.3390/jcm9051431-
dc.contributor.localIdA02353-
dc.contributor.localIdA02037-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA02267-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid32408478-
dc.subject.keywordElizabethkingia-
dc.subject.keywordanti-bacterial agent-
dc.subject.keywordmicrobial sensitivity tests-
dc.subject.keywordmortality-
dc.subject.keywordrisk factors-
dc.contributor.alternativeNameYeom, Joon Sup-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.contributor.affiliatedAuthor안진영-
dc.citation.volume9-
dc.citation.number5-
dc.citation.startPage1431-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.9(5) : 1431, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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