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ID1-Mediated BMP Signaling Pathway Potentiates Glucagon-Like Peptide-1 Secretion in Response to Nutrient Replenishment
DC Field | Value | Language |
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dc.contributor.author | 이해경 | - |
dc.contributor.author | 황성순 | - |
dc.date.accessioned | 2020-09-28T11:32:27Z | - |
dc.date.available | 2020-09-28T11:32:27Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179222 | - |
dc.description.abstract | Glucagon-like peptide-1 (GLP-1) is a well-known incretin hormone secreted from enteroendocrinal L cells in response to nutrients, such as glucose and dietary fat, and controls glycemic homeostasis. However, the detailed intracellular mechanisms of how L cells control GLP-1 secretion in response to nutrients still remain unclear. Here, we report that bone morphogenetic protein (BMP) signaling pathway plays a pivotal role to control GLP-1 secretion in response to nutrient replenishment in well-established mouse enteroendocrinal L cells (GLUTag cells). Nutrient starvation dramatically reduced cellular respiration and GLP-1 secretion in GLUTag cells. Transcriptome analysis revealed that nutrient starvation remarkably reduced gene expressions involved in BMP signaling pathway, whereas nutrient replenishment rescued BMP signaling to potentiate GLP-1 secretion. Transient knockdown of inhibitor of DNA binding (ID)1, a well-known target gene of BMP signaling, remarkably reduced GLP-1 secretion. Consistently, LDN193189, an inhibitor of BMP signaling, markedly reduced GLP-1 secretion in L cells. In contrast, BMP4 treatment activated BMP signaling pathway and potentiated GLP-1 secretion in response to nutrient replenishment. Altogether, we demonstrated that BMP signaling pathway is a novel molecular mechanism to control GLP-1 secretion in response to cellular nutrient status. Selective activation of BMP signaling would be a potent therapeutic strategy to stimulate GLP-1 secretion in order to restore glycemic homeostasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | ID1-Mediated BMP Signaling Pathway Potentiates Glucagon-Like Peptide-1 Secretion in Response to Nutrient Replenishment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Jae Woong Jeong | - |
dc.contributor.googleauthor | Minki Kim | - |
dc.contributor.googleauthor | Jiwoo Lee | - |
dc.contributor.googleauthor | Hae-Kyung Lee | - |
dc.contributor.googleauthor | Younhee Ko | - |
dc.contributor.googleauthor | Hyunkyung Kim | - |
dc.contributor.googleauthor | Sungsoon Fang | - |
dc.identifier.doi | 10.3390/ijms21113824 | - |
dc.contributor.localId | A05936 | - |
dc.contributor.localId | A05443 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 32481541 | - |
dc.subject.keyword | L cells | - |
dc.subject.keyword | bone morphogenetic protein 4 | - |
dc.subject.keyword | glucagon-like peptide-1 | - |
dc.subject.keyword | incretin | - |
dc.subject.keyword | inhibitor of DNA binding 1 | - |
dc.contributor.alternativeName | Lee, Hae-Kyung | - |
dc.contributor.affiliatedAuthor | 이해경 | - |
dc.contributor.affiliatedAuthor | 황성순 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3824 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(11) : 3824, 2020-05 | - |
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