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Treatment of refractory IgA vasculitis with dapsone: a systematic review

DC FieldValueLanguage
dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2020-09-28T11:30:05Z-
dc.date.available2020-09-28T11:30:05Z-
dc.date.issued2020-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179209-
dc.description.abstractIgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved 13 articles published until June 14, 2018. The most common clinical feature was a palpable rash (100% of patients), followed by joint pain (69.2%). Treatment response within 1-2 days was observed in 6 of 26 patients (23.1%) versus within 3-7 days in 17 patients (65.4%). Relapse after treatment discontinuation was reported in 17 patients (65.4%) but not in 3 patients (11.5 %). Four of the 26 patients (15.4%) reported adverse effects of dapsone including arthralgia (7.7%), rash (7.7%), and dapsone hypersensitivity syndrome (3.8%). Our findings suggest that dapsone may affect refractory IgA vasculitis. Multicenter randomized placebo-controlled trials are necessary to determine the standard dosage of dapsone at initial or tapering of treatment in IgA vasculitis patients and evaluate whether dapsone has a significant benefit versus steroids or other medications.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Pediatric Society-
dc.relation.isPartOfClinical and Experimental Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTreatment of refractory IgA vasculitis with dapsone: a systematic review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorSung Hwi Hong-
dc.contributor.googleauthorJinhae Jun-
dc.contributor.googleauthorYoungheun Jo-
dc.contributor.googleauthorWoogyeong Jo-
dc.contributor.googleauthorDayeon Choi-
dc.contributor.googleauthorJeongho Joo-
dc.contributor.googleauthorGuhyun Jung-
dc.contributor.googleauthorSunghee Ahn-
dc.contributor.googleauthorAndreas Kronbichler-
dc.contributor.googleauthorMichael Eisenhut-
dc.contributor.googleauthorJae Il Shin-
dc.identifier.doi10.3345/kjp.2019.00514-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03867-
dc.identifier.eissn2713-4148-
dc.identifier.pmid32024340-
dc.subject.keywordDapsone-
dc.subject.keywordHenoch-Schonlein purpura-
dc.subject.keywordIgA vasculitis-
dc.subject.keywordSystematic review-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이금화-
dc.contributor.affiliatedAuthor이금화-
dc.citation.volume63-
dc.citation.number5-
dc.citation.startPage158-
dc.citation.endPage163-
dc.identifier.bibliographicCitationClinical and Experimental Pediatrics, Vol.63(5) : 158-163, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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