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Effects of 1% Lidocaine Instillation on Overactive Bladder Induced by Bladder Outlet Obstruction in Rats

DC FieldValueLanguage
dc.contributor.author강효진-
dc.contributor.author이용승-
dc.contributor.author김상운-
dc.contributor.author김장환-
dc.contributor.author한상원-
dc.date.accessioned2020-09-28T11:29:42Z-
dc.date.available2020-09-28T11:29:42Z-
dc.date.issued2020-05-
dc.identifier.issn1735-1308-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179206-
dc.description.abstractPurpose: Lidocaine is a common local anesthetic and antiarrhythmic drug that acts via the local anesthetic effect of blocking voltage-gated sodium channels in peripheral neurons. To evaluate lidocaine as a therapeutic agent, we investigated optimal concentrations and effects of intravesical lidocaine instillation in a bladder outlet obstruction (BOO)-induced rat model of overactive bladder (OAB). Materials and methods: To determine the therapeutic dosage of lidocaine, 16 female Sprague-Dawley (SD) rats (mean weight = 200 ± 20 g) were divided into four treatment groups: those receiving saline, 0.5% lidocaine, 1% lidocaine, and 2% lidocaine (n = 4 per group). Twenty-four additional SD rats were divided into two groups to investigate the effect of 1% lidocaine treatment in rats with BOO and normal rats (n = 12 per group). Cystometry was performed by infusing physiological saline and lidocaine into the bladder at a slow infusion rate (0.04 mL/min). Cystometric parameters were analyzed using PowerLab®. The expression of c-Fos, a protein expressed by C-fibers in the spinal cord (L6), was investigated via western blotting. Results: Among the test lidocaine doses, only 1% lidocaine increased the intercontraction interval (ICI) (control mean = 500.56 ± 24.4 s; treatment mean = 641.0 ± 49.3 s; p < .01) without changes in threshold pressure and basal pressure. In the BOO-induced OAB group, the ICI increased significantly after instillation of 1% lidocaine (control mean = 135.8 ± 12.87 s; OAB-group mean = 274.2 ± 33.21 s; p < .01). Detrusor overactivity and non-voiding contraction were observed in the control group but not in rats with BOO after lidocaine instillation. The expression of c-Fos in C-fibers in the spinal cord (L6) decreased significantly after 1% lidocaine treatment in rats with BOO. Conclusion: Intravesical instillation of 1% lidocaine improves cystometric parameters without deterioration of contractility by blocking excessive C-fiber activity in the rat model of BOO-induced OAB. Therefore, instillation of 1% lidocaine has minimal effects on normal nerves while blocking nerves that contribute to OAB. Our findings suggest that intravesical instillation of 1% lidocaine is a useful treatment for OAB.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherUrology and Nephrology Research Center-
dc.relation.isPartOfUROLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of 1% Lidocaine Instillation on Overactive Bladder Induced by Bladder Outlet Obstruction in Rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorHyo Jin Kang-
dc.contributor.googleauthorSang Woon Kim-
dc.contributor.googleauthorYong Seung Lee-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorJang Hwan Kim-
dc.identifier.doi10.22037/uj.v0i0.5111-
dc.contributor.localIdA00101-
dc.contributor.localIdA02980-
dc.contributor.localIdA02980-
dc.contributor.localIdA00527-
dc.contributor.localIdA00527-
dc.contributor.localIdA00855-
dc.contributor.localIdA00855-
dc.contributor.localIdA04285-
dc.contributor.localIdA04285-
dc.relation.journalcodeJ02940-
dc.identifier.eissn1735-546X-
dc.identifier.pmid31630385-
dc.contributor.alternativeNameKang, Hyo Jin-
dc.contributor.affiliatedAuthor강효진-
dc.contributor.affiliatedAuthor이용승-
dc.contributor.affiliatedAuthor이용승-
dc.contributor.affiliatedAuthor김상운-
dc.contributor.affiliatedAuthor김상운-
dc.contributor.affiliatedAuthor김장환-
dc.contributor.affiliatedAuthor김장환-
dc.contributor.affiliatedAuthor한상원-
dc.contributor.affiliatedAuthor한상원-
dc.citation.volume17-
dc.citation.number3-
dc.citation.startPage306-
dc.citation.endPage311-
dc.identifier.bibliographicCitationUROLOGY JOURNAL, Vol.17(3) : 306-311, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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