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HIERARCHICAL MIXED-EFFECTS MODEL FOR HIV DYNAMICS

DC FieldValueLanguage
dc.contributor.author최준용-
dc.date.accessioned2020-09-28T11:10:56Z-
dc.date.available2020-09-28T11:10:56Z-
dc.date.issued2020-05-
dc.identifier.issn0036-1399-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179184-
dc.description.abstractA hierarchical mixed-effects model is proposed to account for both individual- and population-level variability in human immunodeficiency virus (HIV) dynamics. This model is implemented by formulating the crucial parameters as random variables in an in-host HIV model. Model reduction is used to guide the choice for a minimal set of parameters, whose distributions are estimated by the global two-stage method. We analyze the system of ordinary differential equations with random coefficients and provide numerical simulations illustrating its asymptotic behaviors.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSociety for Industrial and Applied Mathematics-
dc.relation.isPartOfSIAM JOURNAL ON APPLIED MATHEMATICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHIERARCHICAL MIXED-EFFECTS MODEL FOR HIV DYNAMICS-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYUNJEONG LEE-
dc.contributor.googleauthorYOON-GU HWANG-
dc.contributor.googleauthorHEE-DAE KWON-
dc.contributor.googleauthorJUN YONG CHOI-
dc.contributor.googleauthorJEEHYUN LEE-
dc.identifier.doi10.1137/19M1246031-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ03893-
dc.subject.keywordHIV dynamics-
dc.subject.keywordmixed-effects model-
dc.subject.keywordrandom ODEs-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume80-
dc.citation.number3-
dc.citation.startPage1290-
dc.citation.endPage1306-
dc.identifier.bibliographicCitationSIAM JOURNAL ON APPLIED MATHEMATICS, Vol.80(3) : 1290-1306, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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