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Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response

DC FieldValueLanguage
dc.contributor.author김상우-
dc.contributor.author김민환-
dc.contributor.author김혜련-
dc.contributor.author홍민희-
dc.contributor.author허수진-
dc.contributor.author조병철-
dc.contributor.author박영민-
dc.contributor.author고윤우-
dc.contributor.author김세헌-
dc.contributor.author최은창-
dc.contributor.author윤선옥-
dc.contributor.author김다희-
dc.date.accessioned2020-09-28T11:10:00Z-
dc.date.available2020-09-28T11:10:00Z-
dc.date.issued2020-04-
dc.identifier.issn0007-0920-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179178-
dc.description.abstractBackground: Oropharyngeal cancer (OPC) exhibits diverse immunological properties; however, their implications for immunotherapy are unknown. Methods: We analysed 37 surgically resected and nine recurrent or metastatic anti-programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1)-treated OPC tumours. OPCs were classified into immune-rich (IR), mesenchymal (MS) and xenobiotic (XB) subtypes based on RNA-sequencing data. Results: All IR type tumours were human papillomavirus (HPV) positive, most XB types were HPV negative, and MS types showed mixed HPV status. The IR type showed an enriched T cell exhaustion signature with PD-1+ CD8+ T cells and type I macrophages infiltrating the tumour nest on multiplex immunohistochemistry. The MS type showed an exclusion of CD8+ T cells from the tumour nest and high MS and tumour growth factor-β signatures. The XB type showed scant CD8+ T cell infiltration and focal CD73 expression. The IR type was associated with a favourable response signature during anti-PD-1/PD-L1 therapy and showed a high APOBEC mutation signature, whereas the MS and XB types showed resistance signature upregulation. Among anti-PD-1/PD-L1-treated OPC patients, the IR type showed a favourable clinical response (3/4 patients), whereas the XB type showed early progression (3/3 patients). Conclusion: Our analysis classified OPCs into three subtypes with distinct immune microenvironments that are potentially related to the response to anti-PD-1/PD-L1 therapy.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group on behalf of Cancer Research UK-
dc.relation.isPartOfBRITISH JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMolecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biomedical Systems Informatics (의생명시스템정보학교실)-
dc.contributor.googleauthorMin Hwan Kim-
dc.contributor.googleauthorJae-Hwan Kim-
dc.contributor.googleauthorJi Min Lee-
dc.contributor.googleauthorJae Woo Choi-
dc.contributor.googleauthorDongmin Jung-
dc.contributor.googleauthorHojin Cho-
dc.contributor.googleauthorHyundeok Kang-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorSu Jin Heo-
dc.contributor.googleauthorSe Heon Kim-
dc.contributor.googleauthorEun Chang Choi-
dc.contributor.googleauthorDa Hee Kim-
dc.contributor.googleauthorYoung Min Park-
dc.contributor.googleauthorSangwoo Kim-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorHye Ryun Kim-
dc.identifier.doi10.1038/s41416-020-0796-8-
dc.contributor.localIdA00524-
dc.contributor.localIdA00482-
dc.contributor.localIdA00482-
dc.contributor.localIdA01166-
dc.contributor.localIdA01166-
dc.contributor.localIdA04393-
dc.contributor.localIdA04393-
dc.contributor.localIdA04355-
dc.contributor.localIdA04355-
dc.contributor.localIdA03822-
dc.contributor.localIdA03822-
dc.contributor.localIdA01566-
dc.contributor.localIdA01566-
dc.contributor.localIdA00133-
dc.contributor.localIdA00133-
dc.contributor.localIdA00605-
dc.contributor.localIdA00605-
dc.contributor.localIdA04161-
dc.contributor.localIdA04161-
dc.contributor.localIdA02566-
dc.contributor.localIdA02566-
dc.relation.journalcodeJ00406-
dc.identifier.eissn1532-1827-
dc.identifier.pmid32235905-
dc.contributor.alternativeNameKim, Sang Woo-
dc.contributor.affiliatedAuthor김상우-
dc.contributor.affiliatedAuthor김민환-
dc.contributor.affiliatedAuthor김민환-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor홍민희-
dc.contributor.affiliatedAuthor홍민희-
dc.contributor.affiliatedAuthor허수진-
dc.contributor.affiliatedAuthor허수진-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor박영민-
dc.contributor.affiliatedAuthor박영민-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor김세헌-
dc.contributor.affiliatedAuthor김세헌-
dc.contributor.affiliatedAuthor최은창-
dc.contributor.affiliatedAuthor최은창-
dc.contributor.affiliatedAuthor윤선옥-
dc.contributor.affiliatedAuthor윤선옥-
dc.citation.volume122-
dc.citation.number11-
dc.citation.startPage1649-
dc.citation.endPage1660-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF CANCER, Vol.122(11) : 1649-1660, 2020-04-
dc.identifier.rimsid67525-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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