Cited 15 times in
Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.date.accessioned | 2020-09-28T10:37:30Z | - |
dc.date.available | 2020-09-28T10:37:30Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 0014-2972 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179163 | - |
dc.description.abstract | Background: Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method: We searched PubMed and investigated the results of meta-analyses published through November 2018. We re-assessed the results based on false-positive report probability (FPRP) to test the noteworthiness of the associations. Results: Sixty-eight miRNA polymorphisms in 45 meta-analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR-146a/rs2910164 Cvs.G; miR-27a/rs895819 Cvs.T; miR-423/rs6505162 Cvs.A; and miR-605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR-196a2/rs11614913 Tvs.C; miR-27a/rs895819 GGvs.AA + AG; miR-196a2/rs11614913 C vs.T; miR-146a/rs2910164 Gvs.C; miR-196a2/rs11614913 Tvs.C; miR-146a/rs2910164 Cvs.G; miR-499/rs3746444 homozygous model; miR-146a/rs2910164 CCvs.GG + GC; miR-499/rs3746444 TCvs.TT; miR-499/rs3746444 GAvs.AA; miR-146a/rs2910164 CCvs.GG; and miR-499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001. Conclusion: Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Jae Hyon Park | - |
dc.contributor.googleauthor | Gwang Hun Jeong | - |
dc.contributor.googleauthor | Kwang Seob Lee | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Jin-Soon Suh | - |
dc.contributor.googleauthor | Michael Eisenhut | - |
dc.contributor.googleauthor | Hans J van der Vliet | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.contributor.googleauthor | Brendon Stubbs | - |
dc.contributor.googleauthor | Marco Solmi | - |
dc.contributor.googleauthor | Elena Dragioti | - |
dc.contributor.googleauthor | Ai Koyanagi | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Gabriele Gamerith | - |
dc.identifier.doi | 10.1111/eci.13203 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.relation.journalcode | J00814 | - |
dc.identifier.eissn | 1365-2362 | - |
dc.identifier.pmid | 31984489 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/eci.13203 | - |
dc.subject.keyword | FPRP | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | gene variant | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | microRNA | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.contributor.affiliatedAuthor | 이금화 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e13203 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.50(4) : e13203, 2020-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.