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Effects of Multidrug-resistant Bacteria in Donor Lower Respiratory Tract on Early Posttransplant Pneumonia in Lung Transplant Recipients Without Pretransplant Infection

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dc.contributor.author송영구-
dc.contributor.author박무석-
dc.contributor.author이경화-
dc.contributor.author김송이-
dc.contributor.author정수진-
dc.contributor.author한상훈-
dc.contributor.author백효채-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author라연주-
dc.date.accessioned2020-09-28T10:37:04Z-
dc.date.available2020-09-28T10:37:04Z-
dc.date.issued2020-04-
dc.identifier.issn0041-1337-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179162-
dc.description.abstractBackground: Multidrug-resistant (MDR) bacteria in the lower respiratory tracts of allografts may be risk factors for early posttransplant pneumonia (PTP) that causes detrimental outcomes in lung transplant recipients (LTRs). We evaluated the effects of immediate changes in MDR bacteria in allografts on early PTP and mortality rates in LTRs. Methods: We reviewed 90 adult bilateral LTRs without pretransplant infections who underwent lung transplantation between October 2012 and May 2018. Quantitative cultures were performed with the bronchoalveolar lavage fluids of the allografts preanastomosis and within 3 days posttransplant. The International Society for Heart and Lung Transplantation consensus defines early PTP as pneumonia acquired within 30 days posttransplant and not associated with acute rejection. Results: MDR Acinetobacter baumannii (11/34, 32.4%) and Staphylococcus aureus (9/34, 26.5%) were identified in 24.4% (22/90) of the preanastomosis allografts. Four LTRs had the same MDR bacteria in allografts preanastomosis and posttransplant. Allograft MDR bacteria disappeared in 50% of the LTRs within 3 days posttransplant. Early PTP and all-cause in-hospital mortality rates were not different between LTRs with and without preanastomosis MDR bacteria (P = 0.75 and 0.93, respectively). MDR bacteria ≥10 CFU/mL in the lungs within 3 days posttransplant was associated with early PTP (odds ratio, 5.8; 95% confidence interval, 1.3-27.0; P = 0.03). Conclusions: High levels of preexisting MDR bacteria in allografts did not increase early PTP and mortality rates in LTRs. Despite the small and highly selective study population, lung allografts with MDR bacteria may be safely transplanted with appropriate posttransplant antibiotic therapy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfTRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of Multidrug-resistant Bacteria in Donor Lower Respiratory Tract on Early Posttransplant Pneumonia in Lung Transplant Recipients Without Pretransplant Infection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKyoung Hwa Lee-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorSeul Gi Yoo-
dc.contributor.googleauthorYeonju La-
dc.contributor.googleauthorDa Eun Kwon-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorYong Goo Song-
dc.contributor.googleauthorHyo Chae Paik-
dc.identifier.doi10.1097/TP.0000000000003102-
dc.contributor.localIdA02037-
dc.contributor.localIdA01457-
dc.contributor.localIdA04620-
dc.contributor.localIdA00626-
dc.contributor.localIdA03638-
dc.contributor.localIdA04286-
dc.contributor.localIdA01846-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.relation.journalcodeJ02754-
dc.identifier.eissn1534-6080-
dc.identifier.pmid31895333-
dc.identifier.urlhttps://journals.lww.com/transplantjournal/Fulltext/2020/04000/Effects_of_Multidrug_resistant_Bacteria_in_Donor.22.aspx-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor김송이-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor한상훈-
dc.contributor.affiliatedAuthor백효채-
dc.contributor.affiliatedAuthor이진구-
dc.contributor.affiliatedAuthor이창영-
dc.citation.volume104-
dc.citation.number4-
dc.citation.startPagee98-
dc.citation.endPagee106-
dc.identifier.bibliographicCitationTRANSPLANTATION, Vol.104(4) : e98-e106, 2020-04-
dc.identifier.rimsid67502-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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