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Single-center risk factor analysis for FOLFIRINOX associated febrile neutropenia in patients with pancreatic cancer

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dc.contributor.author송시영-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author정문재-
dc.contributor.author방승민-
dc.contributor.author금지영-
dc.contributor.author이희승-
dc.contributor.author조중현-
dc.contributor.author강화평-
dc.date.accessioned2020-09-28T02:51:05Z-
dc.date.available2020-09-28T02:51:05Z-
dc.date.issued2020-04-
dc.identifier.issn0344-5704-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179142-
dc.description.abstractPurpose: FOLFIRINOX is the standard therapy in patients with unresectable pancreatic cancer (PC). However, FOLFIRINOX frequently induces febrile neutropenia (FN) and neutropenia. The purpose of this study was to explore risk factors for FN and grade 4 neutropenia (NP G4) in patients receiving FOLFIRINOX for PC. Methods: We collected data on 106 patients with PC treated with first-line FOLFIRINOX between 2015 and 2017 using the Pancreatic Cancer Cohort Registry of Severance Hospital in Seoul, Korea. Results: Multivariate logistic regression analysis showed that female (OR, 3.24; P = 0.023), Eastern Cooperative Oncology Group performance status (OR, 3.70; P = 0.024), overweight (OR, 4.25; P = 0.022), and initial biliary stent insertion (OR, 4.22; P = 0.008) were significantly related to a high risk of FN. Time-dependent bias was reduced using Cox regression analysis, which revealed that female (OR, 2.29; P = 0.041), overweight (OR, 2.67; P = 0.022), and initial biliary stent insertion (OR, 2.59; P = 0.016) were statistically significant predictors. Regarding NP G4, female sex (OR, 2.90; P = 0.016) and overweight (OR, 4.07; P = 0.033) were identified as risk factors in multivariate analysis; however, in Cox regression analysis, tumor in the head of the pancreas (OR, 1.96; P = 0.027) and hemoglobin (g/dL < 12) (OR, 1.87; P = 0.049) were also identified as risk factors. Conclusion: Female sex, overweight, and initial biliary stent insertion were independent risk factors for the occurrence of FN in patients with unresectable PC treated with FOLFIRINOX.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Verlag-
dc.relation.isPartOfCANCER CHEMOTHERAPY AND PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSingle-center risk factor analysis for FOLFIRINOX associated febrile neutropenia in patients with pancreatic cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJiyoung Keum-
dc.contributor.googleauthorHee Seung Lee-
dc.contributor.googleauthorHuapyong Kang-
dc.contributor.googleauthorJung Hyun Jo-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorSeungmin Bang-
dc.identifier.doi10.1007/s00280-020-04051-x-
dc.contributor.localIdA02035-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA03602-
dc.contributor.localIdA01786-
dc.relation.journalcodeJ00437-
dc.identifier.eissn1432-0843-
dc.identifier.pmid32185483-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00280-020-04051-x-
dc.subject.keywordChemotherapy-
dc.subject.keywordFebrile neutropenia-
dc.subject.keywordNeutropenia-
dc.subject.keywordPancreatic cancer-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.affiliatedAuthor송시영-
dc.contributor.affiliatedAuthor박승우-
dc.contributor.affiliatedAuthor박정엽-
dc.contributor.affiliatedAuthor정문재-
dc.contributor.affiliatedAuthor방승민-
dc.citation.volume85-
dc.citation.number4-
dc.citation.startPage651-
dc.citation.endPage659-
dc.identifier.bibliographicCitationCANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol.85(4) : 651-659, 2020-04-
dc.identifier.rimsid67557-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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