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Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites

Authors
 Jeong-Kee Yoon  ;  Dae-Hyun Kim  ;  Mi-Lan Kang  ;  Hyeon-Ki Jang  ;  Hyun-Ji Park  ;  Jung Bok Lee  ;  Se Won Yi  ;  Hye-Seon Kim  ;  Sewoom Baek  ;  Dan Bi Park  ;  Jin You  ;  Seong-Deok Lee  ;  Yoshitaka Sei  ;  Song Ih Ahn  ;  Young Min Shin  ;  Chang Soo Kim  ;  Sangsu Bae  ;  YongTae Kim  ;  Hak-Joon Sung 
Citation
 SMALL, Vol.16(16) : e2000012, 2020-04 
Journal Title
 SMALL 
ISSN
 1613-6810 
Issue Date
2020-04
Keywords
atherosclerosis ; disturbed blood flow ; mesenchymal stem cells ; nanovesicles ; plasmid design
Abstract
Atherosclerosis development leads to irreversible cascades, highlighting the unmet need for improved methods of early diagnosis and prevention. Disturbed flow formation is one of the earliest atherogenic events, resulting in increased endothelial permeability and subsequent monocyte recruitment. Here, a mesenchymal stem cell (MSC)-derived nanovesicle (NV) that can target disturbed flow sites with the peptide GSPREYTSYMPH (PREY) (PMSC-NVs) is presented which is selected through phage display screening of a hundred million peptides. The PMSC-NVs are effectively produced from human MSCs (hMSCs) using plasmid DNA designed to functionalize the cell membrane with PREY. The potent anti-inflammatory and pro-endothelial recovery effects are confirmed, similar to those of hMSCs, employing mouse and porcine partial carotid artery ligation models as well as a microfluidic disturbed flow model with human carotid artery-derived endothelial cells. This nanoscale platform is expected to contribute to the development of new theragnostic strategies for preventing the progression of atherosclerosis.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.202000012
DOI
10.1002/smll.202000012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kang, Mi-Lan(강미란)
Kim, Dae-Hyun(김대현)
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Shin, Young Min(신영민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179141
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