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Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model

DC Field Value Language
dc.contributor.author이용찬-
dc.contributor.author김원호-
dc.contributor.author정다현-
dc.contributor.author김원호-
dc.contributor.author정다현-
dc.date.accessioned2020-09-28T02:48:06Z-
dc.date.available2020-09-28T02:48:06Z-
dc.date.issued2020-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179128-
dc.description.abstractNew antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of H. pylori in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-H.pylori efficacy of β-caryophyllene, a total of 160 mice were divided into eight groups (n = 10 each) and were administered different treatments for 2 and 4 weeks. H. pylori eradication was assessed using a Campylobacter-like organism (CLO) test and H. pylori qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively. H. pylori levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in H. pylori-infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of H. pylori infection.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI Publishing-
dc.relation.isPartOfNUTRIENTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorMi Hee Park-
dc.contributor.googleauthorChul Jin Kim-
dc.contributor.googleauthorJin Young Lee-
dc.contributor.googleauthorChang Yeop Keum-
dc.contributor.googleauthorIn Seon Kim-
dc.contributor.googleauthorChang-Hyun Yun-
dc.contributor.googleauthorSung-Kyu Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorYong Chan Lee-
dc.identifier.doi10.3390/nu12041000-
dc.contributor.localIdA02988-
dc.contributor.localIdA00774-
dc.contributor.localIdA00774-
dc.contributor.localIdA03591-
dc.contributor.localIdA03591-
dc.contributor.localIdA00774-
dc.contributor.localIdA00774-
dc.contributor.localIdA03591-
dc.contributor.localIdA03591-
dc.relation.journalcodeJ02396-
dc.identifier.eissn2072-6643-
dc.identifier.pmid32260414-
dc.subject.keywordHelicobacter pylori-
dc.subject.keyworderadication-
dc.subject.keywordβ-caryophyllene-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthor이용찬-
dc.contributor.affiliatedAuthor김원호-
dc.contributor.affiliatedAuthor김원호-
dc.contributor.affiliatedAuthor정다현-
dc.contributor.affiliatedAuthor정다현-
dc.contributor.affiliatedAuthor김원호-
dc.contributor.affiliatedAuthor김원호-
dc.contributor.affiliatedAuthor정다현-
dc.contributor.affiliatedAuthor정다현-
dc.citation.volume12-
dc.citation.number4-
dc.citation.startPage1000-
dc.identifier.bibliographicCitationNUTRIENTS, Vol.12(4) : 1000, 2020-04-
dc.identifier.rimsid67481-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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