Cited 14 times in
Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 정다현 | - |
dc.date.accessioned | 2020-09-28T02:48:06Z | - |
dc.date.available | 2020-09-28T02:48:06Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179128 | - |
dc.description.abstract | New antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of H. pylori in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-H.pylori efficacy of β-caryophyllene, a total of 160 mice were divided into eight groups (n = 10 each) and were administered different treatments for 2 and 4 weeks. H. pylori eradication was assessed using a Campylobacter-like organism (CLO) test and H. pylori qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively. H. pylori levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in H. pylori-infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of H. pylori infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI Publishing | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Da Hyun Jung | - |
dc.contributor.googleauthor | Mi Hee Park | - |
dc.contributor.googleauthor | Chul Jin Kim | - |
dc.contributor.googleauthor | Jin Young Lee | - |
dc.contributor.googleauthor | Chang Yeop Keum | - |
dc.contributor.googleauthor | In Seon Kim | - |
dc.contributor.googleauthor | Chang-Hyun Yun | - |
dc.contributor.googleauthor | Sung-Kyu Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.identifier.doi | 10.3390/nu12041000 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A03591 | - |
dc.relation.journalcode | J02396 | - |
dc.identifier.eissn | 2072-6643 | - |
dc.identifier.pmid | 32260414 | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | eradication | - |
dc.subject.keyword | β-caryophyllene | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | 이용찬 | - |
dc.contributor.affiliatedAuthor | 김원호 | - |
dc.contributor.affiliatedAuthor | 정다현 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1000 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, Vol.12(4) : 1000, 2020-04 | - |
dc.identifier.rimsid | 67481 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.